Porphyromonas gingivalis Virulence Factors and Clinical Significance in Periodontal Disease and Coronary Artery Diseases.
Porphyromonas gingivalis Virulence Factors and Clinical Significance in Periodontal Disease and Coronary Artery Diseases.
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DOI：
10.3390/pathogens11101173
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发表时间：
2022-10-11
期刊：
影响因子：
--
通讯作者：
Talapko J
中科院分区：
文献类型：
--
作者：
Aleksijević LH;Aleksijević M;Škrlec I;Šram M;Šram M;Talapko J
牙龈卟啉单胞菌是一种革兰氏阴性厌氧菌，生活在口腔中。它是口腔微生物组的一个组成部分，其中包括500多种细菌。在某些情况下，作为毒力因子的结果，它可以变得非常具有破坏性，并在牙周病变中增殖到许多细胞。它是牙菌斑中最常见的致病因子之一，是牙周病发展的主要病因。在各种治疗过程中，牙龈卟啉单胞菌可以进入血液并通过血液传播到远处的器官。这主要是指牙周制剂对亚急性心内膜炎发展的影响，并可促进冠心病、动脉粥样硬化和缺血性梗死的发展。牙龈卟啉单胞菌的作用是由许多毒力和致病性因子促进的，如菌毛、溶血素、血凝素、荚膜、外膜囊泡、脂多糖和牙龈卟啉菌蛋白酶。一个特殊的问题是生物膜形成的可能性。生物膜中的牙龈卟啉单胞菌对抗微生物药物的敏感性比嗜酸细胞低500至1000倍，这代表了治疗由该病原体引起的感染的显著问题。
Porphyromonas gingivalis is a gram-negative, anaerobic bacterium that lives in the oral cavity. It is an integral part of the oral microbiome, which includes more than 500 types of bacteria. Under certain circumstances, as a consequence of virulence factors, it can become very destructive and proliferate to many cells in periodontal lesions. It is one of the causative agents present extremely often in dental plaque and is the main etiological factor in the development of periodontal disease. During various therapeutic procedures, P. gingivalis can enter the blood and disseminate through it to distant organs. This primarily refers to the influence of periodontal agents on the development of subacute endocarditis and can facilitate the development of coronary heart disease, atherosclerosis, and ischemic infarction. The action of P. gingivalis is facilitated by numerous factors of virulence and pathogenicity such as fimbriae, hemolysin, hemagglutinin, capsules, outer membrane vesicles, lipopolysaccharides, and gingipains. A special problem is the possibility of biofilm formation. P. gingivalis in a biofilm is 500 to 1000 times less sensitive to antimicrobial drugs than planktonic cells, which represents a significant problem in the treatment of infections caused by this pathogen.
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影响因子：
39.3
作者：
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通讯作者：
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4.6
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