Deep brain stimulation of the nucleus accumbens shell attenuates cue-induced reinstatement of both cocaine and sucrose seeking in rats.
Deep brain stimulation of the nucleus accumbens shell attenuates cue-induced reinstatement of both cocaine and sucrose seeking in rats.
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DOI：
10.1016/j.bbr.2014.12.025
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发表时间：
2015-03-15
影响因子：
2.7
通讯作者：
Pierce, R. Christopher
中科院分区：
文献类型：
--
作者：
Guercio, Leonardo A.;Schmidt, Heath D.;Pierce, R. Christopher
关键词：
先前与吸毒相关的刺激可能成为诱因，引发渴望并导致觅药行为复发。在此，我们研究了伏隔核壳部的深部脑刺激（DBS）对线索诱导的可卡因觅药行为复燃的影响，这是一种复发的动物模型。大鼠被允许每天自行注射可卡因（0.254毫克，静脉注射）2小时，持续21天，每次注射可卡因都伴有提示灯亮起。在自行注射21天后，通过在无提示灯的情况下用生理盐水替代可卡因来消除摄毒行为。接下来，在复燃阶段，在再次暴露于先前与可卡因强化相关的线索之前，立即通过双极不锈钢电极双侧对伏隔核壳部进行DBS。DBS在2小时的复燃过程中持续进行。平行研究考察了伏隔核壳部DBS对先前与蔗糖强化相关的线索诱导的复燃的影响。结果表明，伏隔核壳部的DBS显著减弱了线索诱导的可卡因和蔗糖觅药行为的复燃。总之，这些结果表明伏隔核壳部的DBS破坏了与药物和天然强化物相关的线索诱导的复燃。
Stimuli previously associated with drug taking can become triggers that can elicit craving and lead to relapse of drug-seeking behavior. Here, we examined the influence of deep brain stimulation (DBS) in the nucleus accumbens shell on cue-induced reinstatement of cocaine seeking, an animal model of relapse. Rats were allowed to self-administer cocaine (0.254 mg, i.v.) for 2 h daily for 21 d, with each infusion of cocaine being paired with a cue light. After 21 d of self-administration, cocaine-taking behavior was extinguished by replacing cocaine with saline in the absence of the cue light. Next, during the reinstatement phase, DBS was administered bilaterally into the nucleus accumbens shell through bipolar stainless steel electrodes immediately prior to re-exposure to cues previously associated with cocaine reinforcement. DBS continued throughout the 2 h reinstatement session. Parallel studies examined the influence of accumbens shell DBS on reinstatement induced by cues previously associated with sucrose reinforcement. Results indicated that DBS of the nucleus accumbens shell significantly attenuated cue-induced reinstatement of cocaine and sucrose seeking. Together, these results indicate that DBS of the accumbens shell disrupts cue-induced reinstatement associated with both a drug and a natural reinforcer.
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DOI：
10.1523/jneurosci.5277-07.2008
发表时间：
2008-08-27
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Vassoler FM;Schmidt HD;Gerard ME;Famous KR;Ciraulo DA;Kornetsky C;Knapp CM;Pierce RC
通讯作者：
Pierce RC
影响因子：
3.7
作者：
Lin, Peagan;Pratt, Wayne E.
通讯作者：
Pratt, Wayne E.
影响因子：
16.2
作者：
Mayberg, HS;Lozano, AM;Kennedy, SH
通讯作者：
Kennedy, SH
伏隔核 DBS 对自我给药大鼠海洛因寻求行为的影响
影响因子：
4.2
作者：
Guo, Liemei;Zhou, Hongyu;Jiang, Jiyao
通讯作者：
Jiang, Jiyao
影响因子：
3.1
作者：
Grubert, Christiane;Hurlemann, Rene;Schlaepfer, Thomas E.
通讯作者：
Schlaepfer, Thomas E.