Bone and Muscle Crosstalk in Aging.
Bone and Muscle Crosstalk in Aging.
复制标题
衰老过程中的骨骼和肌肉串扰
DOI：
10.3389/fcell.2020.585644
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发表时间：
2020
影响因子：
5.5
通讯作者：
Li C
中科院分区：
文献类型：
--
作者：
He C;He W;Hou J;Chen K;Huang M;Yang M;Luo X;Li C
Osteoporosis and sarcopenia are two age-related diseases that affect the quality of life in the elderly. Initially, they were thought to be two independent diseases; however, recently, increasing basic and clinical data suggest that skeletal muscle and bone are both spatially and metabolically connected. The term “osteosarcopenia” is used to define a condition of synergy of low bone mineral density with muscle atrophy and hypofunction. Bone and muscle cells secrete several factors, such as cytokines, myokines, and osteokines, into the circulation to influence the biological and pathological activities in local and distant organs and cells. Recent studies reveal that extracellular vesicles containing microRNAs derived from senescent skeletal muscle and bone cells can also be transported and aid in regulating bone-muscle crosstalk. In this review, we summarize the age-related changes in the secretome and extracellular vesicle-microRNAs secreted by the muscle and bone, and discuss their interactions between muscle and bone cells during aging.
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激活素A-乳腺抑制素系统对衰老的骨骼和肌肉祖细胞的影响。
影响因子：
3.9
作者：
Bowser, Matthew;Herberg, Samuel;Arounleut, Phonepasong;Shi, Xingming;Fulzele, Sadanand;Hill, William D.;Isales, Carlos M.;Hamrick, Mark W.
通讯作者：
Hamrick, Mark W.
影响因子：
82.9
作者：
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通讯作者：
Pap, Thomas
影响因子：
4
作者：
Chung, Ping-Lin;Zhou, Shuanhu;Eslami, Behnam;Shen, Longxiang;LeBoff, Meryl S.;Glowacki, Julie
通讯作者：
Glowacki, Julie
影响因子：
3.3
作者：
Chang, Jae Seung;Kim, Tae Ho;Kong, In Deok
通讯作者：
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影响因子：
4.5
作者：
Chang, Jae Seung;Kong, In Deok
通讯作者：
Kong, In Deok