Targeting epigenetic mechanisms for chronic visceral pain: A valid approach for the development of novel therapeutics.
Targeting epigenetic mechanisms for chronic visceral pain: A valid approach for the development of novel therapeutics.
复制标题
DOI：
10.1111/nmo.13500
复制
发表时间：
2019-03
影响因子：
3.5
通讯作者：
Greenwood-Van Meerveld B
中科院分区：
文献类型：
--
作者：
Louwies T;Ligon CO;Johnson AC;Greenwood-Van Meerveld B
慢性内脏痛是从胸部、盆腔或腹部起源的持续性疼痛，其对于受影响的特定器官定位不良。成人人群中的患病率可高达25%，因为慢性内脏痛是许多内脏疾病的共同特征，这些疾病可能伴有或不伴有内脏器官内明显的结构或组织学异常。越来越多的证据表明，表观遗传机制的变化参与了自上而下或自下而上的疼痛通路敏化和慢性疼痛的发展。表观遗传变化可导致神经元基因表达谱的长期改变，从而改变外周神经元、背根神经节（DRG）、脊髓和脑神经元的功能。然而，表观遗传修饰是动态的，因此有害的变化可能是可逆的。因此，外部因素/治疗干预可能能够调节表观基因组并在延长的时间段内恢复正常基因表达。这篇综述的目的是强调最新的发现，了解参与慢性内脏痛的发展或维持的表观遗传机制。此外，这篇综述将提供证据支持靶向这些表观遗传机制可能代表治疗慢性内脏痛的新方法。
Chronic visceral pain is persistent pain emanating from thoracic, pelvic or abdominal origin that is poorly localized with regard to the specific organ affected. The prevalence can range up to 25% in the adult population as chronic visceral pain is a common feature of many visceral disorders which may or may not be accompanied by distinct structural or histological abnormalities within the visceral organs. Mounting evidence suggest that changes in epigenetic mechanisms are involved in the top-down or bottom-up sensitization of pain pathways and the development of chronic pain. Epigenetic changes can lead to long-term alterations in gene expression profiles of neurons and consequently alter functionality of peripheral neurons, dorsal root ganglia (DRG), spinal cord, and brain neurons. However, epigenetic modifications are dynamic and thus detrimental changes may be reversible. Hence, external factors/therapeutic interventions may be capable of modulating the epigenome and restore normal gene expression for extended periods of time. The goal of this review is to highlight the latest discoveries made towards understanding the epigenetic mechanisms that are involved in the development or maintenance of chronic visceral pain. Furthermore, this review will provide evidence supporting that targeting these epigenetic mechanisms may represent a novel approach to treat chronic visceral pain.
登录
查看更多内容
影响因子：
4.2
作者：
Chouliaras L;van den Hove DL;Kenis G;Keitel S;Hof PR;van Os J;Steinbusch HW;Schmitz C;Rutten BP
通讯作者：
Rutten BP
DOI：
10.1016/j.omtn.2017.06.005
发表时间：
2017-09-15
期刊：
Molecular therapy. Nucleic acids
影响因子：
--
作者：
Chakraborty C;Sharma AR;Sharma G;Doss CGP;Lee SS
通讯作者：
Lee SS
DOI：
10.1152/ajpgi.00500.2004
发表时间：
2005-07-01
影响因子：
4.5
作者：
Bradesi, S;Schwetz, I;Mayer, EA
通讯作者：
Mayer, EA
影响因子：
7.4
作者：
Doehring, Alexandra;Oertel, Bruno Georg;Loetsch, Joern
通讯作者：
Loetsch, Joern
影响因子：
16.2
作者：
Braz J;Solorzano C;Wang X;Basbaum AI
通讯作者：
Basbaum AI