Transmitting pain and itch messages: a contemporary view of the spinal cord circuits that generate gate control.
Transmitting pain and itch messages: a contemporary view of the spinal cord circuits that generate gate control.
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DOI：
10.1016/j.neuron.2014.01.018
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发表时间：
2014-05-07
期刊：
影响因子：
16.2
通讯作者：
Basbaum AI
中科院分区：
文献类型：
--
作者：
Braz J;Solorzano C;Wang X;Basbaum AI
门控理论（GCT）的最初表述提出，由脊髓信号传导到大脑产生的疼痛的感知取决于大直径（非伤害性）和小直径（伤害性）初级传入纤维中产生的活动的平衡。GCT提出，大直径传入神经的激活通过接合抑制投射神经元放电的浅表背角中间神经元来“关闭”门。伤害感受器的激活通过伴随的投射神经元的兴奋和抑制性中间神经元的抑制“打开”门。在GCT发表60年后，我们面临着一个不断增长的在形态学和神经化学上不同的脊髓中间神经元的列表。这篇综述强调了浅表背角回路的复杂性，并讨论了GCT中概述的前提在今天是否仍然具有相关性。通过检查“疼痛”和“瘙痒”信息传输背后的背角回路，我们还讨论了标记线可以在多大程度上纳入GCT的当代观点。
The original formulation of Gate Control Theory (GCT) proposed that the perception of pain produced by spinal cord signaling to the brain depends on a balance of activity generated in large (non-nociceptive) and small (nociceptive) diameter primary afferent fibers. GCT proposed that activation of the large diameter afferent “closes” the gate by engaging a superficial dorsal horn interneuron that inhibits projection neuron firing. Activation of the nociceptors “opens” the gate through concomitant excitation of projection neurons and inhibition of inhibitory interneurons. Sixty years after publication of the GCT, we are faced with an ever-growing list of morphologically and neurochemically distinct spinal cord interneurons. This review highlights the complexity of superficial dorsal horn circuitry and addresses whether the premises outlined in GCT still have relevance today. By examining the dorsal horn circuits underlying the transmission of “pain” and “itch” messages, we also address the extent to which labeled lines can be incorporated into a contemporary view of GCT.
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DOI：
10.1073/pnas.0700293104
发表时间：
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影响因子：
11.1
作者：
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通讯作者：
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作者：
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影响因子：
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作者：
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DOI：
10.1002/cne.22081
发表时间：
2009-08-20
期刊：
The Journal of comparative neurology
影响因子：
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作者：
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通讯作者：
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