The potential value of CDV3 in the prognosis evaluation in Hepatocellular carcinoma.

The potential value of CDV3 in the prognosis evaluation in Hepatocellular carcinoma.
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CDV3在肝细胞癌预后评估中的潜在价值

DOI:
10.1016/j.gendis.2018.01.003
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发表时间:
2018-06
期刊:
影响因子:
6.8
通讯作者:
Du C
Du C
中科院分区:
医学2区
文献类型:
--
作者:
Xiao H;Zhou B;Jiang N;Cai Y;Liu X;Shi Z;Li M;Du C

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CDV3与肿瘤发生有关,并可能影响肿瘤的某些生物学过程。在本研究中,我们探讨了CDV3在HCC中的作用。根据TCGA数据库,CDV3在HCC组织中过表达。在HCC患者中,CDV3的上调与较低的总生存率相关。在我院的HCC样本中,CDV3也在癌组织中富集,且CDV3的表达与HCC病理性T分期相关。此外,较高的CDV3表达可以预测HCC患者的生存率较低。综上所述,CDV3是HCC的生物标志物,可能是一个潜在的治疗靶点。
CDV3 is correlated with tumorigenesis and may affect some biological process in cancer. In this study, we explore the role of CDV3 in HCC. According to the TCGA data base, CDV3 is over-expressed in HCC tissues. Up-regulation of CDV3 is correlated with lower over-all survival rate in HCC patients. In HCC samples from our hospital, CDV3 is also enriched in cancer tissues and CDV3 expression associated with HCC pathological T stage. What is more, higher CDV3 expression could forecast poor survival rate in HCC patients. In conclusion, CDV3 is a biomarker of HCC and could be a potential therapeutic target.
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