Rapid processing of fearful faces relies on the right amygdala: evidence from individuals undergoing unilateral temporal lobectomy.
Rapid processing of fearful faces relies on the right amygdala: evidence from individuals undergoing unilateral temporal lobectomy.
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DOI：
10.1038/s41598-020-80054-1
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发表时间：
2021-01-11
影响因子：
4.6
通讯作者：
Pegna AJ
中科院分区：
文献类型：
--
作者：
Framorando D;Moses E;Legrand L;Seeck M;Pegna AJ
情绪的面部表情已被证明可以调节早期ERP成分，特别是N170。产生这些早期效应的潜在解剖结构尚不清楚。在这项研究中，我们研究了N170增强的恐惧表达在健康对照以及癫痫患者后，单侧左或右杏仁核切除。我们观察到一个更大的N170的恐惧的面孔在健康的参与者以及在个人与左杏仁核切除。相比之下，在接受手术切除右侧杏仁核的患者中没有观察到这种效果。这一结果表明，杏仁核对恐惧的面孔产生了早期的大脑反应。这种早期反应特别依赖于右杏仁核，发生在大约170毫秒。这种增加很可能是由于纹外皮层的反应增强，这种反应通过快速的杏仁核投射到视觉区域而发生。
Facial expressions of emotions have been shown to modulate early ERP components, in particular the N170. The underlying anatomical structure producing these early effects are unclear. In this study, we examined the N170 enhancement for fearful expressions in healthy controls as well as epileptic patients after unilateral left or right amygdala resection. We observed a greater N170 for fearful faces in healthy participants as well as in individuals with left amygdala resections. By contrast, the effect was not observed in patients who had undergone surgery in which the right amygdala had been removed. This result demonstrates that the amygdala produces an early brain response to fearful faces. This early response relies specifically on the right amygdala and occurs at around 170 ms. It is likely that such increases are due to a heightened response of the extrastriate cortex that occurs through rapid amygdalofugal projections to the visual areas.
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