A comparison of DXA and CT based methods for estimating the strength of the femoral neck in post-menopausal women.
A comparison of DXA and CT based methods for estimating the strength of the femoral neck in post-menopausal women.
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DOI：
10.1007/s00198-012-2066-y
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发表时间：
2013-04
影响因子：
4
通讯作者：
Cauley, J. A.
中科院分区：
文献类型：
--
作者：
Danielson, M. E.;Beck, T. J.;Karlamangla, A. S.;Greendale, G. A.;Atkinson, E. J.;Lian, Y.;Khaled, A. S.;Keaveny, T. M.;Kopperdahl, D.;Ruppert, K.;Greenspan, S.;Vuga, M.;Cauley, J. A.
骨强度的简单二维（2D）分析可以用双能X射线吸收测定法（DXA）数据进行，并应用于大型数据集。我们比较了基于定量计算机断层扫描（QCT）数据的二维分析和三维（3D）有限元分析（FEA）。参加全国妇女健康研究（SWAN）的213名妇女接受了髋关节DXA和QCT扫描。DXA骨密度和股骨颈直径和轴长被用来估计几何复合弯曲（BSI）和压缩强度（CSI）指数。将髋关节结构分析（HSA）在相同DXA数据上计算的这些和可比指数与使用QCT几何结构的指数进行比较。使用HSA和QCT股骨颈几何结构生成跌倒撞击大转子的简单2D工程模拟;这些估计值以跌倒撞击的3D FEA为基准。由BMD和HSA计算的DXA衍生CSI和BSI彼此相关良好（R= 0.92和0.70），并与QCT衍生指数相关良好（R= 0.83-0.85和0.65-0.72）。使用HSA几何结构的2D强度估计值与QCT（R=0.76）和3D FEA估计值（R=0.56）相关性良好。HSA根据DXA数据计算的股骨颈几何结构与QCT计算的股骨颈几何结构相当，足以在更大的SWAN数据集中分析载荷应力。来自BMD数据的几何形状也表现得差不多。根据2D DXA数据估计的股骨近端断裂强度与使用QCT数据通过3D FEA得出的断裂强度相关性不佳。
Simple 2-dimensional (2D) analyses of bone strength can be done with dual energy x-ray absorptiometry (DXA) data and applied to large data sets. We compared 2D analyses to 3-dimensional (3D) finite element analyses (FEA) based on quantitative computed tomography (QCT) data. 213 women participating in the Study of Women’s Health across the Nation (SWAN) received hip DXA and QCT scans. DXA BMD and femoral neck diameter and axis length were used to estimate geometry for composite bending (BSI) and compressive strength (CSI) indices. These and comparable indices computed by Hip Structure Analysis (HSA) on the same DXA data were compared to indices using QCT geometry. Simple 2D engineering simulations of a fall impacting on the greater trochanter were generated using HSA and QCT femoral neck geometry; these estimates were benchmarked to a 3D FEA of fall impact. DXA-derived CSI and BSI computed from BMD and by HSA correlated well with each other (R= 0.92 and 0.70) and with QCT-derived indices (R= 0.83–0.85 and 0.65–0.72). The 2D strength estimate using HSA geometry correlated well with that from QCT (R=0.76) and with the 3D FEA estimate (R=0.56). Femoral neck geometry computed by HSA from DXA data corresponds well enough to that from QCT for an analysis of load stress in the larger SWAN data set. Geometry derived from BMD data performed nearly as well. Proximal femur breaking strength estimated from 2D DXA data is not as well correlated with that derived by a 3D FEA using QCT data.
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影响因子：
6.2
作者：
Orwoll, Eric S.;Marshall, Lynn M.;Keaveny, Tony M.
通讯作者：
Keaveny, Tony M.
影响因子：
2.4
作者：
Keyak, JH;Rossi, SA;Skinner, HB
通讯作者：
Skinner, HB
影响因子：
6.2
作者：
Burge, Russel;Dawson-Hughes, Bess;Tosteson, Anna
通讯作者：
Tosteson, Anna
影响因子：
6.7
作者：
BECK, TJ;RUFF, CB;RAO, GU
通讯作者：
RAO, GU
影响因子：
56.9
作者：
CARTER, DR;HAYES, WC
通讯作者：
HAYES, WC