Polarity proteins regulate mammalian cell-cell junctions and cancer pathogenesis.
Polarity proteins regulate mammalian cell-cell junctions and cancer pathogenesis.
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DOI：
10.1016/j.ceb.2009.07.003
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发表时间：
2009-10
影响因子：
7.5
通讯作者：
Muthuswamy SK
中科院分区：
文献类型：
--
作者：
Feigin ME;Muthuswamy SK
多细胞生物的上皮细胞形成高度组织化的组织，专门负责保护、分泌和吸收的任务，所有这些都需要严格调节细胞极性和组织结构的核心过程。这些核心过程的破坏是上皮性肿瘤的一个关键特征。细胞极性和组织结构密切相关，因为控制细胞形状的蛋白质还负责细胞-细胞连接和三维组织组织的正确定位和组装。上皮组织下方的细胞外基质支持组织结构，并通过调节细胞粘附和激活保护性信号级联来抑制恶性生长。新的证据正在揭示极性途径改变上皮细胞组织方式以及与组织微环境相互作用的机制，从而促进肿瘤发生过程中的异常生长和侵袭。我们讨论了细胞极性途径如何调节细胞与细胞的连接，并强调了通过研究极性途径在上皮细胞转化过程中所发挥的作用而获得的新见解。
The epithelial cells of multicellular organisms form highly organized tissues specialized for the tasks of protection, secretion and absorption, all of which require tight regulation of the core processes of cell polarity and tissue architecture. Disruption of these core processes is a critical feature of epithelial tumors. Cell polarity and tissue architecture are intimately linked, as proteins controlling cell shape are also responsible for proper localization and assembly of cell-cell junctions and three-dimensional tissue organization. The extracellular matrix underlying epithelial tissues supports tissue architecture and suppresses malignant growth through regulation of cell adhesion and activation of protective signaling cascades. Emerging evidence is uncovering the mechanisms by which polarity pathways alter the way epithelial cells organize and interact with the tissue microenvironment to promote aberrant growth and invasion during tumorigenesis. We discuss how cell polarity pathways regulate cell-cell junctions and highlight the new insights gained by investigating the role played by polarity pathways during transformation of epithelial cells.
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影响因子：
3.3
作者：
Lemmers, C;Michel, D;Le Bivic, A
通讯作者：
Le Bivic, A
影响因子：
64.8
作者：
Betschinger, J;Mechtler, K;Knoblich, JA
通讯作者：
Knoblich, JA
DOI：
10.1083/jcb.132.6.1115
发表时间：
1996-03
期刊：
The Journal of cell biology
影响因子：
--
作者：
Fialka I;Schwarz H;Reichmann E;Oft M;Busslinger M;Beug H
通讯作者：
Beug H
影响因子：
4.8
作者：
Laprise, P;Viel, A;Rivard, N
通讯作者：
Rivard, N
影响因子：
8
作者：
Dow, L. E.;Elsum, I. A.;Humbert, P. O.
通讯作者：
Humbert, P. O.