Induction of IgA circulating immune complexes after wheat feeding in dermatitis herpetiformis patients.
Induction of IgA circulating immune complexes after wheat feeding in dermatitis herpetiformis patients.
复制标题
疱疹样皮炎患者喂食小麦后 IgA 循环免疫复合物的诱导。
DOI：
10.1111/1523-1747.ep12507494
复制
发表时间：
1982
期刊：
影响因子：
--
通讯作者：
T. Provost
中科院分区：
文献类型：
--
作者：
J. Zone;B. LaSalle;T. Provost
疱疹样皮肤炎是一种以皮肤乳头中伊加沉积为特征的疾病，并伴有通常无症状的谷蛋白敏感性肠病。然而，小麦制品和皮肤病之间的致病关系知之甚少。本研究的目的是评估短期的伊加和IgG循环免疫复合物口服摄入小麦和非小麦膳食蛋白。5名疱疹样皮炎患者和5名正常对照喂食全麦，每30分钟收集一次血清。5小时后，给予无麸质膳食，每小时收集血清，再持续5小时。伊加循环免疫复合物和IgG循环免疫复合物使用Raji细胞免疫放射测定法测量。疱疹样皮炎患者，作为一个群体，制定了一个显着的伊加循环免疫复合物水平的升高，但不是IgG循环免疫复合物水平，小麦摄入后。正常人，作为一个群体，未能发展一个显着的升高（无论是伊加或IgG循环免疫复合物小麦摄入后。5例疱疹样皮炎患者中有5例出现伊加循环免疫复合物诱导，其中2例伊加循环免疫复合物水平先前正常。这些结果表明：（1）在疱疹样皮炎患者中，可诱导伊加循环免疫复合物的升高，其水平先前为正常水平，（2）伊加循环免疫复合物水平与已知改变疾病活动性的因素有关，即小麦摄入，和（3）免疫复合物应答是伊加介导的疾病中伊加的特征。这些结果支持伊加循环免疫复合物在疱疹样皮炎的免疫发病机制中发挥生物学重要作用的假设。
Dermatitis herpetiformis is a disorder characterized by deposition of IgA in the dermal papillae and an associated gluten-sensitive enteropathy which is frequently asymptomatic. However, the pathogenic relationship between wheat products and the skin disease is poorly understood. The present study was designed to assess the short-term response of IgA and IgG circulating immune complexes to oral ingestion of wheat and nonwheat dietary protein. Five patients with dermatitis herpetiformis and 5 normal controls were fed whole wheat and serum was collected every 30mm. After 5hr, a gluten-free meal was given and serum was collected hourly for 5 more hours. IgA circulating immune complexes and IgG circulating immune complexes were measured using the Raji cell immunoradiometric assay. Patients with dermatitis herpetiformis, as a group, developed a significant elevation of IgA circulating immune complex levels, but not IgG circulating immune complex levels, after wheat ingestion. Normals, as a group, failed to develop a significant elevation of (either IgA or IgG circulating immune complexes after wheat ingestion. Induction of IgA circulating immune complexes was demonstrated in 5 of 5 patients with dermatitis herpetiformis, including 2 patients with previously normal levels of IgA circulating immune complexes. These results indicate that: (1) elevation of igA circulating immune complexes can be induced in patients with dermatitis herpetiformis with previously normal levels, (2) IgA circulating immune complex levels are related to a factor known to alter disease activity, namely wheat ingestion, and (3) the immune complex response is characteristic for IgA in a disease felt to be IgA mediated. These results support the hypothesis that IgA circulating immune complexes play a biologically significant role in the immunopathogenesis of dermatitis herpetiformis.
疱疹样皮炎中 IgA 型循环免疫复合物。
DOI：
10.1111/1523-1747.ep12522539
发表时间：
1980
期刊：
The Journal of investigative dermatology
影响因子：
--
作者：
Zone,JJ;LaSalle,BA;Provost,TT
通讯作者：
Provost,TT