Potential molecular mechanisms mediating the protective effects of tetrahydroxystilbene glucoside on MPP+-induced PC12 cell apoptosis
Potential molecular mechanisms mediating the protective effects of tetrahydroxystilbene glucoside on MPP+-induced PC12 cell apoptosis
复制标题
四羟基芪葡萄糖苷对 MPP 诱导的 PC12 细胞凋亡保护作用的潜在分子机制
DOI：
10.1007/s11010-017-3169-8
复制
发表时间：
2017-08
期刊：
影响因子：
--
通讯作者：
Jianzong Chen
中科院分区：
文献类型：
--
作者：
Lingling Zhang;Linhong Huang;Xiaobing Li;Cuicui Liu;Xin Sun;Leitao Wu;Tao Li;Hao Yang;Jianzong Chen
Our previous work demonstrated that tetrahydroxystilbene glucoside (TSG) was able to effectively attenuate 1-methyl-4-phenylpyridinium (MPP+)-induced apoptosis in PC12 cells partially via inhibiting reactive oxygen species (ROS) generation. However, the precise molecular mechanisms of TSG responsible for suppressing neuronal apoptosis have not been fully elucidated. To investigate the possible mechanism, we studied the neuroprotective effects of TSG on MPP+-induced PC12 cells apoptosis and explored the molecular mechanisms that mediated the effects of TSG. Our results showed that treatment with TSG prior to MPP+exposure effectively attenuated the cell viability decrease in PC12 cells, reversed the cell apoptosis, and further restored the mitochondria membrane potential (MMP). In addition, TSG remarkably enhanced the anti-oxidant enzyme activities of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px), and efficiently reduced the malondialdehyde (MDA) content in the PC12 cells. Meanwhile, TSG markedly upregulated the Bcl-2/Bax ratio, reversed release of Cytochrome c, and inhibited the activation of caspase-3 induced by MPP+. Furthermore, TSG significantly inhibited the activation of p38 mitogen-activated protein kinase (p38MAPK) signaling pathway, while extracellular signal-regulated protein kinases (ERK) phosphorylation was not affected. Together, these findings provide the basis for TSG clinical application as a new therapeutic strategy in the treatment of neurodegenerative diseases.
登录
查看更多内容
影响因子：
7.4
作者：
Kuo HC;Lu CC;Shen CH;Tung SY;Hsieh MC;Lee KC;Lee LY;Chen CC;Teng CC;Huang WS;Chen TC;Lee KF
通讯作者：
Lee KF
用于多巴胺能神经元的神经保护和帕金森病的潜在治疗的中草药和草药提取物。
DOI：
10.2174/187152707781387288
发表时间：
2007-07
期刊：
CNS & neurological disorders drug targets
影响因子：
--
作者：
通讯作者：
--
人参皂苷 Rg1 通过针对黑质中的 α-突触核蛋白异常减轻 MPTP 丙磺舒诱发的帕金森病小鼠模型中的运动障碍和神经炎症
影响因子：
3.5
作者：
Heng, Yang;Zhang, Qiu-Shuang;Chen, Nai-Hong
通讯作者：
Chen, Nai-Hong
影响因子：
4.2
作者：
Zhou, Xuanxuan;Yang, Qian;Wang, Siwang
通讯作者：
Wang, Siwang
影响因子：
7.2
作者：
A. Maghsoudi;Saideh Fakharzadeh;M. Hafizi;M. Abbasi;Fatemeh Kohram;Shima Sardab;A. Tahzibi;S. Kalanaky;M. Nazaran
通讯作者：
A. Maghsoudi;Saideh Fakharzadeh;M. Hafizi;M. Abbasi;Fatemeh Kohram;Shima Sardab;A. Tahzibi;S. Kalanaky;M. Nazaran