Luteolin protects mice from severe acute pancreatitis by exerting HO-1-mediated anti-inflammatory and antioxidant effects.
Luteolin protects mice from severe acute pancreatitis by exerting HO-1-mediated anti-inflammatory and antioxidant effects.
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木犀草素通过发挥 HO-1 介导的抗炎和抗氧化作用，保护小鼠免受严重急性胰腺炎的侵害
DOI：
10.3892/ijmm.2016.2809
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发表时间：
2017-01
影响因子：
5.4
通讯作者：
Wang X
中科院分区：
文献类型：
--
作者：
Xiong J;Wang K;Yuan C;Xing R;Ni J;Hu G;Chen F;Wang X
Reseda odorata L. has long been used in traditional Asian medicine for the treatment of diseases associated with oxidative injury and acute inflammation, such as endotoxemia, acute lung injury, acute myocardial infarction and hepatitis. Luteolin, the main component of Reseda odorata L., which is also widely found in many natural herbs and vege tables, has been shown to induce heme oxygenase-1 (HO-1) expression to exert anti-inflammatory and antioxidant effects. In this study, we aimed to examine the effects of luteolin on mice with severe acute pancreatitis (SAP), and to explore the underlying mechanisms. Cerulein and lipopolysaccharide were used to induce SAP in male Institute of Cancer Research (ICR) mice in the SAP group. The SAP group was divided into 4 subgroups, as follows: the vehicle, luteolin, zinc protoporphyrin (ZnPP) only, and luteolin (Lut) + ZnPP (luteolin plus zinc protoporphyrin treatment) groups. The wet/dry weight ratios, hematoxylin and eosin staining and pathological scores of pancreatic tissues were assessed and compared to those of the control mice. Amylase, lipase, nuclear factor-κB (NF-κB) and myeloperoxidase activities, and malondialdehyde, tumor necrosis factor α (TNFα), interleukin (IL)-6, IL-10 and HO-1 levels, as well as the expression of HO-1 were determined in serum and/or pancreatic tissue samples. SAP was successfully induced in male mice compared to normal control mice. The wet/dry weight ratios, pathological scores, and amylase and lipase activity, as well as the levels of TNFα and IL-6 were significantly reduced in the pancreatic tissues of the mice in the Lut group compared with those of the mice in the vehicle group. The Lut group exhibited a significant increase in HO-1 expression in the pancreas and enhanced serum HO-1 and IL-10 levels compared with the vehicle group. The suppression of HO-1 activity in the ZnPP group significantly abolished the protective effects of luteolin. NF-κB expression in the pancreatic tissues from the mice in the Lut + ZnPP group was significantly increased following the suppression of HO-1 activity. On the whole, our findings demonstrate that luteolin protects mice from SAP by inducing HO-1-mediated anti-inflammatory and antioxidant activities, in association with the suppression of the activation of the NF-κB pathway.
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DOI：
10.1152/ajpgi.00231.2010
发表时间：
2011-01-01
影响因子：
4.5
作者：
Habtezion, Aida;Kwan, Raymond;Omary, M. Bishr
通讯作者：
Omary, M. Bishr
影响因子：
29.4
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影响因子：
5.6
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Minelli, Alba
DOI：
10.1111/j.1749-6632.2011.06107.x
发表时间：
2011-01-01
期刊：
NUTRITION AND PHYSICAL ACTIVITY IN AGING, OBESITY, AND CANCER
影响因子：
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作者：
Kim, Hyeyoung
通讯作者：
Kim, Hyeyoung
DOI：
10.1164/rccm.201106-1152oc
发表时间：
2012-04-15
影响因子：
24.7
作者：
MacGarvey, Nancy Chou;Suliman, Hagir B.;Piantadosi, Claude A.
通讯作者：
Piantadosi, Claude A.