Carbohydrate complexity limits microbial growth and reduces the sensitivity of human gut communities to perturbations.
Carbohydrate complexity limits microbial growth and reduces the sensitivity of human gut communities to perturbations.
复制标题
DOI：
10.1038/s41559-022-01930-9
复制
发表时间：
2023-01
影响因子：
16.8
通讯作者：
中科院分区：
文献类型：
--
作者：
膳食纤维会影响人类肠道微生物群的生长动力学，但我们对这些营养素如何塑造微生物相互作用网络和对扰动的反应缺乏详细和定量的了解。通过建立人类肠道社区与计算建模相结合，我们剖析了化学复杂性范围内的纤维及其每种组成糖对社区组装和对扰动的反应的影响。我们证明了不同纤维的化学复杂程度限制了微生物的生长和可以利用这些营养物质的物种数量。负物种间相互作用的患病率在纤维的存在下比其组成单糖减少。碳水化合物的化学复杂性增强了群落组装的可重复性和群落对入侵的抵抗力。我们证明，最大限度地提高或降低居民和入侵物种之间的碳水化合物竞争增强抵抗入侵。总之，碳水化合物化学复杂性对微生物相互作用网络的定量影响可以用来通知饮食和细菌干预，以调节社区对扰动的抵抗力。
Dietary fiber impacts the growth dynamics of human gut microbiota, yet we lack an detailed and quantitative understanding of how these nutrients shape microbial interaction networks and response to perturbations. By building human gut communities coupled to computational modeling, we dissect the effects of fibers that range in chemical complexity and each of their constituent sugars on community assembly and response to perturbations. We demonstrate that the degree of chemical complexity across different fibers limits microbial growth and the number of species that can utilize these nutrients. The prevalence of negative inter-species interactions is reduced in the presence of fibers than their constituent monosaccharides. Carbohydrate chemical complexity enhances the reproducibility of community assembly and resistance of the community to invasion. We demonstrate that maximizing or minimizing carbohydrate competition between resident and invader species enhances resistance to invasion. In sum, the quantitative effects of carbohydrate chemical complexity on microbial interaction networks could be exploited to inform dietary and bacterial interventions to modulate community resistance to perturbations.
登录
查看更多内容
DOI：
10.1007/s12275-016-5461-9
发表时间：
2016-01
期刊：
Journal of microbiology (Seoul, Korea)
影响因子：
--
作者：
Deng YJ;Wang SY
通讯作者：
Wang SY
影响因子：
4.4
作者：
Devendran, Saravanan;Shrestha, Rachana;Ridlon, Jason M.
通讯作者：
Ridlon, Jason M.
影响因子：
5.2
作者：
Benítez-Páez A;Moreno FJ;Sanz ML;Sanz Y
通讯作者：
Sanz Y
影响因子：
5.2
作者：
Dai T;Fuchs BB;Coleman JJ;Prates RA;Astrakas C;St Denis TG;Ribeiro MS;Mylonakis E;Hamblin MR;Tegos GP
通讯作者：
Tegos GP
影响因子：
16.6
作者：
Clark RL;Connors BM;Stevenson DM;Hromada SE;Hamilton JJ;Amador-Noguez D;Venturelli OS
通讯作者：
Venturelli OS