The redoxome: Proteomic analysis of cellular redox networks.

The redoxome: Proteomic analysis of cellular redox networks.
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DOI:
10.1016/j.cbpa.2010.11.013
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发表时间:
2011-02
影响因子:
7.8
通讯作者:
Jakob U
Jakob U
中科院分区:
生物学2区
文献类型:
--
作者:
Thamsen M;Jakob U

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氧化还原调节蛋白不仅在机体抵抗氧化应激条件的防御过程中发挥着重要的作用,而且也是细胞信号事件的靶标。这一认识刺激了蛋白质组学技术的发展,这些技术旨在表征氧化染色体;具有高活性半胱氨酸残基的蛋白质,其硫醇氧化态控制着蛋白质的功能,进而控制着它们所处的途径。我们将在此总结氧化还原蛋白质组学分析领域的最新进展,旨在阐明细胞氧化还原网络似乎控制着原核和真核生物。
Redox-regulated proteins play fundamentally important roles not only during the defense of organisms against oxidative stress conditions but also as targets of cellular signaling events. This realization has spurred the development of proteomic techniques geared towards characterizing the redoxome; proteins with highly reactive cysteine residues, whose thiol oxidation state controls the function of the proteins, and by extension, the pathways they are part of. We will here summarize the most recent advances made in the field of redox proteomic analyses, aimed to elucidate the cellular redox networks that appear to control pro- and eukaryotic organisms.
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