Understanding B-cell activation and autoantibody repertoire selection in systemic lupus erythematosus: A B-cell immunomics approach.
Understanding B-cell activation and autoantibody repertoire selection in systemic lupus erythematosus: A B-cell immunomics approach.
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DOI：
10.1111/imr.12660
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发表时间：
2018-07
影响因子：
8.7
通讯作者：
Sanz I
中科院分区：
文献类型：
--
作者：
Tipton CM;Hom JR;Fucile CF;Rosenberg AF;Sanz I
了解抗体库，特别是表达潜在致病抗体的B细胞的特性和命运，对于确定包括自身免疫和变态反应在内的多种免疫性疾病的发病机制以及移植排斥反应至关重要。此外，对不同功能特性和寿命的B细胞和浆细胞(PC)表达的抗体库的综合知识对于开发新的治疗策略、更好的疾病分割生物标志物以及衡量B细胞耐受性恢复或至少正常B细胞稳态的新方法是至关重要的。然而，要实现这些目标，将需要对B细胞和PC群体进行更精确的表型、功能和分子定义，并对它们所表达的抗体的抗原反应性进行全面分析。虽然传统上人体实验受到技术和伦理限制的阻碍，但新的技术进步目前使研究人员能够以全面的方式解决这些问题。在这篇综述中，我们将讨论这些概念在系统性红斑狼疮研究中的应用。
Understanding antibody repertoires and in particular, the properties and fates of B cells expressing potentially pathogenic antibodies is critical to define the mechanisms underlying multiple immunological diseases including autoimmune and allergic conditions as well as transplant rejection. Moreover, an integrated knowledge of the antibody repertoires expressed by B cells and plasma cells (PC) of different functional properties and longevity is essential to develop new therapeutic strategies, better biomarkers for disease segmentation, and new assays to measure restoration of B cell tolerance or, at least, of normal B cell homeostasis. Reaching these goals, however, will require a more precise phenotypic, functional and molecular definition of B-cell and PC populations, and a comprehensive analysis of the antigenic reactivity of the antibodies they express. While traditionally hampered by technical and ethical limitations in human experimentation, new technological advances currently enable investigators to address these questions in a comprehensive fashion. In this review, we shall discuss these concepts as they apply to the study of Systemic Lupus Erythematosus.
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