Perinatally Human Immunodeficiency Virus-Infected Adolescents and Young Adults Demonstrate Distinct BNT162b2 Messenger RNA Coronavirus Disease 2019 Vaccine Immunogenicity.
Perinatally Human Immunodeficiency Virus-Infected Adolescents and Young Adults Demonstrate Distinct BNT162b2 Messenger RNA Coronavirus Disease 2019 Vaccine Immunogenicity.
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DOI：
10.1093/cid/ciac408
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发表时间：
2022-08-15
期刊：
影响因子：
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对具有不同免疫力的易感人群进行免疫接种，往往导致免疫原性、持久性和有效性达不到最佳水平。在28名接受抗逆转录病毒治疗（ART）的围产期HIV感染患者和65名没有COVID-19病史的健康对照（hc）中，对BNT162b2信使RNA冠状病毒病2019 （COVID-19）疫苗在人类免疫缺陷病毒（HIV）感染者中的安全性和免疫原性进行了评估。因此，我们测量了严重急性呼吸综合征冠状病毒2 （SARS-CoV-2）特异性体液和CD4+ T细胞反应。分别在接种前（基线，第0天）、第二次接种时（第21天）和接种后4周（第28天）和6个月（第180天）采集样本。D0和D28的蛋白质组学分析采用多路接近扩展法（Olink）对血浆样品进行评估。所有hiv感染患者的抗sars - cov -2体液反应与hc患者相似，尽管抗三聚体S滴度在D28时较低（P = 0.01）。只有hiv感染患者的外周血单核细胞在D28时表现出扩增其特异性（CD40L+） CD4+ t细胞群的能力受损。随访6个月时，两组体液滴度保持相似。我们还将基线蛋白水平与体液或细胞反应联系起来，确定了参与免疫反应调节的分子簇，在两个研究组之间具有相反的特征。与HC患者相比，接受art治疗的hiv感染患者的反应具有明显的特征，特别是在蛋白质组室内，这支持他们有资格接受额外剂量，类似于HC方案。与健康个体相比，在入组时CD4 t细胞计数正常且具有不同基线蛋白质组学谱的围产期hiv感染患者在接种BNT162b2疫苗后会产生并维持特异性免疫反应。
Immunization of vulnerable populations with distinct immunity often results in suboptimal immunogenicity, durability, and efficacy. Safety and immunogenicity profiles of BNT162b2 messenger RNA coronavirus disease 2019 (COVID-19) vaccine, among people living with human immunodeficiency virus (HIV), were evaluated in 28 perinatally HIV-infected patients under antiretroviral therapy (ART) and 65 healthy controls (HCs) with no previous history of COVID-19. Thus, we measured severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)–specific humoral and CD4+ T cell responses. Samples were collected before vaccination (baseline, day [D] 0), at the second dose (D21), and at 4 weeks (D28) and 6 months (D180) after D0. Proteomic profiles at D0 and D28 were assessed with a multiplexed proximity extension assay (Olink) on plasma samples. All HIV-infected patients mounted similar anti–SARS-CoV-2 humoral responses to those of HCs, albeit with lower titers of anti-trimeric S at D28 (P = .01). Only peripheral blood mononuclear cells of HIV-infected patients demonstrated at D28 an impaired ability to expand their specific (CD40L+) CD4+ T-cell populations. Similar humoral titers were maintained between the 2 groups at 6-months follow-up. We additionally correlated baseline protein levels to either humoral or cellular responses, identifying clusters of molecules involved in immune response regulation with inverse profiles between the 2 study groups. Responses of ART-treated HIV-infected patients, compared to those of HCs, were characterized by distinct features especially within the proteomic compartment, supporting their eligibility to an additional dose, similarly to the HC schedule. In comparison to healthy individuals, perinatally HIV-infected patients with normal CD4 T-cell counts at the time of enrollment and with distinct baseline proteomic profiles mount and maintain specific immune responses upon BNT162b2 vaccination.
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BNT162B2 mRNA COVID-19疫苗的安全性和功效。
DOI：
10.1056/nejmoa2034577
发表时间：
2020-12-31
期刊：
The New England journal of medicine
影响因子：
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作者：
Polack FP;Thomas SJ;Kitchin N;Absalon J;Gurtman A;Lockhart S;Perez JL;Pérez Marc G;Moreira ED;Zerbini C;Bailey R;Swanson KA;Roychoudhury S;Koury K;Li P;Kalina WV;Cooper D;Frenck RW Jr;Hammitt LL;Türeci Ö;Nell H;Schaefer A;Ünal S;Tresnan DB;Mather S;Dormitzer PR;Şahin U;Jansen KU;Gruber WC;C4591001 Clinical Trial Group
通讯作者：
C4591001 Clinical Trial Group
DOI：
10.1093/cid/ciaa1605
发表时间：
2021-10-05
期刊：
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
影响因子：
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作者：
Geretti AM;Stockdale AJ;Kelly SH;Cevik M;Collins S;Waters L;Villa G;Docherty A;Harrison EM;Turtle L;Openshaw PJM;Baillie JK;Sabin CA;Semple MG
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Lou, Xiaoming
线粒体功能在ART控制的PLHIV的CD4 T细胞中受到损害。
影响因子：
7.3
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Zhao J;Schank M;Wang L;Li Z;Nguyen LN;Dang X;Cao D;Khanal S;Nguyen LNT;Thakuri BKC;Ogbu SC;Lu Z;Wu XY;Morrison ZD;Gazzar ME;Liu Y;Zhang J;Ning S;Moorman JP;Yao ZQ
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Yao ZQ