The association between two microRNA variants (miR-499, miR-149) and gastrointestinal cancer risk: a meta-analysis.
The association between two microRNA variants (miR-499, miR-149) and gastrointestinal cancer risk: a meta-analysis.
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两种 MicroRNA 变体（miR-499、miR-149）与胃肠道癌症风险之间的关联：荟萃分析
DOI：
10.1371/journal.pone.0081967
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Gao J
中科院分区：
文献类型：
--
作者：
Li L;Sheng Y;Lv L;Gao J
microRNA（miRNAs）是一类调节相应信使RNA（mRNAs）表达的小分子RNA。由于微小RNA的性质和/或成熟的变化，微小RNA中的单核苷酸多态性（SNP）可能会导致癌症易感性。本研究旨在探讨两种miRNA多态性（miR-499 rs3746444和miR-149 rs 2292832）与胃肠道（GI）癌症风险之间的关系。 我们在PubMed、Wiley Online Library、Web of Science和CNKI数据库中检索病例对照研究。11项rs3746444研究和6项rs 2292832研究被纳入我们的荟萃分析。miR-499基因多态性与结直肠癌易感性之间的唯一明显关联是在纯合子比较中发现的（GG vs. AA：OR = 1.66，95%CI：1.02-2.70，Ph = 0.10，P = 0.04）。在种族与肝细胞癌和胃癌风险的亚组分析中未发现显著相关性。在miR-149的隐性模型中发现GI癌症风险略微升高（TT vs. TC+CC：OR = 1.15，95%CI：1.03-1.30，Ph = 0.68，P = 0.02）。按种族对结果进行分层显示隐性模型与亚洲人群之间存在轻微相关性（TT vs. TC+CC：OR = 1.14，95% CI：1.01-1.29，Ph = 0.79，P = 0.03）。目前的荟萃分析表明，miR-499可能与结直肠癌的风险有关。miR-149可能会略微增加胃肠道癌易感性的风险，尤其是亚洲人。
MicroRNAs (miRNAs) are small RNA molecules that regulate the expression of corresponding messenger RNAs (mRNAs). Single nucleotide polymorphisms (SNPs) in miRNAs may contribute to cancer susceptibility due to changes in the microRNA’s properties and/or maturation. The present study aimed to investigate the association between two miRNA polymorphisms (miR-499 rs3746444 and miR-149 rs2292832) and gastrointestinal (GI) cancer risk. We conducted a search of case-control studies in PubMed, Wiley Online Library, Web of Science and the CNKI database. Eleven rs3746444 studies and six rs2292832 studies were included in our meta-analysis. The only obvious association between the miR-499 polymorphism and colorectal cancer susceptibility was found in the homozygote comparison (GG vs. AA: OR = 1.66, 95% CI: 1.02–2.70, P h = 0.10, P = 0.04). No significant association was found in the subgroup analysis for ethnicity and risk of hepatocellular and gastric cancer. A marginally elevated GI cancer risk was discovered in the recessive model for miR-149 (TT vs. TC+CC: OR = 1.15, 95% CI: 1.03–1.30, P h = 0.68, P = 0.02). Stratifying the results by ethnicity revealed a slight association between the recessive model and the Asian population (TT vs. TC+CC: OR = 1.14, 95% CI: 1.01–1.29, P h = 0.79, P = 0.03). The present meta-analysis indicates that miR-499 may be associated with the risk to colorectal cancer. MiR-149 may confer a marginally increased risk of susceptibility to gastrointestinal cancer, especially for Asians.
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影响因子：
64.8
作者：
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通讯作者：
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