Hematogones in the bone marrow of adults. Immunophenotypic features, clinical settings, and differential diagnosis.
Hematogones in the bone marrow of adults. Immunophenotypic features, clinical settings, and differential diagnosis.
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成人骨髓中的血细胞素。
DOI：
10.1093/ajcp/102.2.202
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发表时间：
1994
影响因子：
3.5
通讯作者：
P. Cornbleet
中科院分区：
文献类型：
--
作者：
R. Davis;T. Longacre;P. Cornbleet
造血细胞（HGs）包括骨髓（BM）中的B系淋巴样前体细胞群，可模拟急性淋巴细胞白血病或淋巴瘤。在儿童中注意到HGs数量增加，但很少有报告描述其在成人中的发生。我们确定了13名成年患者的大量BM淋巴细胞的形态和免疫表型特征的HGs。这些患者的共同特征包括（1）BM抽吸物中存在少量淋巴细胞，具有HG的形态学特征;（2）BM活检中不存在细胞学异常或淋巴细胞异常定位;（3）不存在异常形态或CD 10（4）正常骨髓核型;（5）无明显原因的持续性血细胞减少，通常持续较长时间;和（6）无肿瘤性骨髓受累的证据，经临床随访证实。流式细胞术显示表面表达CD 10、CD 19，较低百分比的CD 20，最小程度的CD 22表达，以及有限但多克隆的免疫球蛋白轻链。9例患者既往接受过免疫抑制治疗或骨髓移植或两者，7例为血淋巴瘤。然而，4例病因不明的血细胞减少症患者没有恶性肿瘤或骨髓抑制治疗的既往史。这些研究结果表明成人HGs的临床、形态学和免疫表型特征，并强调了将这些细胞与化疗后残留的骨髓原始细胞区分开来的困难。
Hematogones (HGs) comprise a B-lineage lymphoid precursor cell population in the bone marrow (BM) that may simulate acute lymphoblastic leukemia or lymphoma. Increased numbers of HGs have been noted in children, but few reports describe their occurrence in adults. We identified 13 adult patients with significant numbers of BM lymphoid cells with the morphologic and immunophenotypic features of HGs. Common features in these patients included (1) presence of small numbers of lymphoid cells in the BM aspirate with morphologic features of HGs; (2) absence of cytologic atypia or abnormal localization of lymphoid cells in the BM biopsy; (3) absence of abnormal morphology or CD10 (common acute lymphoblastic leukemia antigen) expression in circulating lymphocytes; (4) normal BM karyotype; (5) persistence of cytopenia(s) without apparent cause, often for a prolonged period of time; and (6) no evidence of neoplastic marrow involvement, confirmed by clinical follow-up. Flow cytometry demonstrated surface expression of CD10, CD19, a lower percentage of CD20, minimal expression of CD22, and limited but polyclonal immunoglobulin light chain. Nine patients had received previous immunosuppressive therapy or BM transplantation or both, seven for hematolymphoid neoplasia. However, four patients with cytopenias of unknown etiology had no antecedent history of malignancy or marrow suppressive therapy. These findings demonstrate the clinical, morphologic, and immunophenotypic features of HGs in adults, and emphasize the difficulty in distinguishing these cells from residual marrow blasts after chemotherapy.
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影响因子：
20.3
作者：
M. Loken;V. O. Shah;Karen L. Dattilio;C. Civin
通讯作者：
M. Loken;V. O. Shah;Karen L. Dattilio;C. Civin
B 细胞慢性淋巴细胞白血病的正常细胞对应物。
影响因子：
20.3
作者：
Freedman,AS;Boyd,AW;Bieber,FR;Daley,J;Rosen,K;Horowitz,JC;Levy,DN;Nadler,LM
通讯作者：
Nadler,LM
通过造血分化抗原鉴定的正常骨髓中常见的急性淋巴细胞白血病抗原阳性淋巴细胞亚群。
影响因子：
20.3
作者：
Ryan,D;Kossover,S;Mitchell,S;Frantz,C;Hennessy,L;Cohen,H
通讯作者：
Cohen,H
B 细胞和 T 细胞谱系淋巴瘤表达常见急性淋巴细胞白血病抗原 (CALLA)。
影响因子：
20.3
作者：
Ritz,J;Nadler,LM;Bhan,AK;Notis-McConarty,J;Pesando,JM;Schlossman,SF
通讯作者：
Schlossman,SF
从正常人骨髓中纯化常见急性淋巴细胞白血病抗原阳性细胞。
影响因子：
20.3
作者：
Hokland,P;Nadler,LM;Griffin,JD;Schlossman,SF;Ritz,J
通讯作者：
Ritz,J