Sensory specializations drive octopus and squid behaviour.
Sensory specializations drive octopus and squid behaviour.
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DOI：
10.1038/s41586-023-05808-z
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发表时间：
2023-04
期刊：
影响因子：
64.8
通讯作者：
Hibbs, Ryan E. E.
中科院分区：
文献类型：
--
作者：
Kang, Guipeun;Allard, Corey A. H.;Valencia-Montoya, Wendy A. A.;van Giesen, Lena;Kim, Jeong Joo;Kilian, Peter B. B.;Bai, Xiaochen;Bellono, Nicholas W. W.;Hibbs, Ryan E. E.
新性状的进化使其能够扩展到新的生态位和行为位。尽管如此，在蛋白质结构、功能和谱系特异性行为的差异之间证明的联系仍然很少。在这里，我们发现章鱼和乌贼都使用头足类特定的趋化反应受体（CRs）来感知各自的海洋环境，但这些受体的结构适应性支持适合不同生理作用的特定分子的感觉。我们发现鱿鱼表达的古老的CRs与相关的烟碱乙酰胆碱受体更接近，而章鱼的CRs则表现出更近的扩张，与它们精心设计的“触觉味觉”感觉系统相一致。结合遗传图谱、生理学和行为分析，我们确定了鱿鱼CRs的创始成员，该CRs可以检测与伏击捕食相关的可溶性苦味分子。我们提出了鱿鱼CR的低温电镜结构，并将其与章鱼CR和烟碱受体进行了比较。这些分析证明了一个进化过渡，从一个祖先的芳香“笼子”，协调可溶性神经递质或味觉剂，到最近的一个章鱼CR疏水结合口袋，捕捉不溶性分子，介导依赖接触的化学感觉。因此，我们的研究为理解蛋白质结构的适应性如何驱动生物体特征和行为的多样化提供了基础。
The evolution of new traits enables expansion into new ecological and behavioural niches. Nonetheless, demonstrated connections between divergence in protein structure, function and lineage-specific behaviours remain rare. Here we show that both octopus and squid use cephalopod-specific chemotactile receptors (CRs) to sense their respective marine environments, but structural adaptations in these receptors support the sensation of specific molecules suited to distinct physiological roles. We find that squid express ancient CRs that more closely resemble related nicotinic acetylcholine receptors, whereas octopuses exhibit a more recent expansion in CRs consistent with their elaborated ‘taste by touch’ sensory system. Using a combination of genetic profiling, physiology and behavioural analyses, we identify the founding member of squid CRs that detects soluble bitter molecules that are relevant in ambush predation. We present the cryo-electron microscopy structure of a squid CR and compare this with octopus CRs and nicotinic receptors. These analyses demonstrate an evolutionary transition from an ancestral aromatic ‘cage’ that coordinates soluble neurotransmitters or tastants to a more recent octopus CR hydrophobic binding pocket that traps insoluble molecules to mediate contact-dependent chemosensation. Thus, our study provides a foundation for understanding how adaptation of protein structure drives the diversification of organismal traits and behaviour.
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影响因子：
64.8
作者：
Jumper J;Evans R;Pritzel A;Green T;Figurnov M;Ronneberger O;Tunyasuvunakool K;Bates R;Žídek A;Potapenko A;Bridgland A;Meyer C;Kohl SAA;Ballard AJ;Cowie A;Romera-Paredes B;Nikolov S;Jain R;Adler J;Back T;Petersen S;Reiman D;Clancy E;Zielinski M;Steinegger M;Pacholska M;Berghammer T;Bodenstein S;Silver D;Vinyals O;Senior AW;Kavukcuoglu K;Kohli P;Hassabis D
通讯作者：
Hassabis D
DOI：
10.1107/s2059798318009324
发表时间：
2018-09-01
期刊：
Acta crystallographica. Section D, Structural biology
影响因子：
--
作者：
Afonine PV;Klaholz BP;Moriarty NW;Poon BK;Sobolev OV;Terwilliger TC;Adams PD;Urzhumtsev A
通讯作者：
Urzhumtsev A
影响因子：
48
作者：
Kucukelbir, Alp;Sigworth, Fred J.;Tagare, Hemant D.
通讯作者：
Tagare, Hemant D.
影响因子：
7.7
作者：
Brams, Marijke;Govaerts, Cedric;Ulens, Chris
通讯作者：
Ulens, Chris
影响因子：
10.7
作者：
Hoang DT;Chernomor O;von Haeseler A;Minh BQ;Vinh LS
通讯作者：
Vinh LS