Molecular marks for epigenetic identification of developmental and cancer stem cells.
Molecular marks for epigenetic identification of developmental and cancer stem cells.
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DOI：
10.1007/s13148-010-0016-0
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发表时间：
2011-04
影响因子：
5.7
通讯作者：
Patra, Aditi
中科院分区：
文献类型：
--
作者：
Patra, Samir Kumar;Deb, Moonmoon;Patra, Aditi
通过DNA的可逆甲基化（在胞嘧啶的碳-5处）和组蛋白的许多可逆修饰的基因的表观遗传调节在正常生理和发育中起重要作用，并且表观遗传失调与发育障碍和各种疾病状态（包括癌症）相关。干细胞具有无限自我更新的能力。与干细胞类似，一些恶性细胞具有无限分裂的能力，被称为癌症干细胞。近年来，表观遗传修饰与干细胞和癌症干细胞重编程之间的直接相关性正在显现。主要的发现是通过对重编程基因产物的研究而获得的，重编程基因产物也被称为全能性的主调节剂和多能性的诱导剂，即OCT 4、NANOG、cMYC、SOX 2、Klf 4和LIN 28。诱导多能性的挑战是将四个重编程基因（Oct 4、Sox 2、Klf 4和c-Myc）插入基因组中。在宿主细胞中，尤其是通过逆转录病毒技术引入时，总是存在通过表观遗传修饰使这些基因沉默的风险。在这篇文章中，我们将讨论与癌症进展和癌症干细胞相关的各种基因的染色质内的表观遗传修饰与干细胞正常发育相比的一些重大发现。这些修饰可以被认为是预测发育障碍和鉴定疾病状态的分子标记。本文的在线版本（doi：10.1007/s13148-010-0016-0）包含补充材料，可供授权用户使用。
Epigenetic regulations of genes by reversible methylation of DNA (at the carbon-5 of cytosine) and numerous reversible modifications of histones play important roles in normal physiology and development, and epigenetic deregulations are associated with developmental disorders and various disease states, including cancer. Stem cells have the capacity to self-renew indefinitely. Similar to stem cells, some malignant cells have the capacity to divide indefinitely and are referred to as cancer stem cells. In recent times, direct correlation between epigenetic modifications and reprogramming of stem cell and cancer stem cell is emerging. Major discoveries were made with investigations on reprogramming gene products, also known as master regulators of totipotency and inducer of pluoripotency, namely, OCT4, NANOG, cMYC, SOX2, Klf4, and LIN28. The challenge to induce pluripotency is the insertion of four reprogramming genes (Oct4, Sox2, Klf4, and c-Myc) into the genome. There are always risks of silencing of these genes by epigenetic modifications in the host cells, particularly, when introduced through retroviral techniques. In this contribution, we will discuss some of the major discoveries on epigenetic modifications within the chromatin of various genes associated with cancer progression and cancer stem cells in comparison to normal development of stem cell. These modifications may be considered as molecular signatures for predicting disorders of development and for identifying disease states. The online version of this article (doi:10.1007/s13148-010-0016-0) contains supplementary material, which is available to authorized users.
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影响因子：
3.7
作者：
Barco R;Garcia CB;Eid JE
通讯作者：
Eid JE
影响因子：
64.8
作者：
Agger, Karl;Cloos, Paul A. C.;Helin, Kristian
通讯作者：
Helin, Kristian
影响因子：
10.5
作者：
CARLSON, LL;PAGE, AW;BESTOR, TH
通讯作者：
BESTOR, TH
DOI：
10.1073/pnas.1734203100
发表时间：
2003-09-30
影响因子：
11.1
作者：
Alonso, L;Fuchs, E
通讯作者：
Fuchs, E
影响因子：
11.2
作者：
Caldwell, GM;Jones, C;Morton, DG
通讯作者：
Morton, DG