Coxiella burnetii Lipopolysaccharide: What Do We Know?

Coxiella burnetii Lipopolysaccharide: What Do We Know?
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DOI:
10.3390/ijms18122509
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发表时间:
2017-11-23
影响因子:
5.6
通讯作者:
Ghigo E
Ghigo E
中科院分区:
生物学2区
文献类型:
--
作者:
Abnave P;Muracciole X;Ghigo E

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贝氏柯克斯体(Coxiellaburnetii,C. burnetii),负责人畜共患病称为Q热。C.贝氏菌是一种细胞内细菌,通过劫持免疫系统的几种功能,可以在杀微生物细胞如单核细胞和巨噬细胞内存活。在众多毒力因子中,C.贝氏体是参与这种免疫劫持的主要因素之一,因为其非典型的组成和结构。因此,本文的目的是总结C。贝氏菌LPS对细胞抗菌免疫的影响。
A small gram-negative bacterium, Coxiella burnetii (C. burnetii), is responsible for a zoonosis called Q fever. C. burnetii is an intracellular bacterium that can survive inside microbicidal cells like monocytes and macrophages by hijacking several functions of the immune system. Among several virulence factors, the lipopolysaccharide (LPS) of C. burnetii is one of the major factors involved in this immune hijacking because of its atypical composition and structure. Thus, the aim of this mini-review is to summarize the repressive effects of C. burnetii LPS on the antibacterial immunity of cells.
通过PD-1-PD-1配体阻滞来振兴耗尽的HIV特异性T细胞。
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