Motion processing streams in Drosophila are behaviorally specialized.

Motion processing streams in Drosophila are behaviorally specialized.
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DOI:
10.1016/j.neuron.2008.05.022
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发表时间:
2008-07-31
期刊:
影响因子:
16.2
通讯作者:
Clandinin TR
Clandinin TR
中科院分区:
医学1区
文献类型:
--
作者:
Katsov AY;Clandinin TR

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运动视觉是一种古老的能力,在一系列行为学背景下对许多动物至关重要,其基本算法为神经计算提供了核心见解。然而,人们对运动线索如何引导行为知之甚少,因为在任何生物体中,实现这些计算的神经电路基本上都是未知的。我们开发了一种系统的、向前的遗传学方法,使用高通量、定量的行为分析来以公正的方式识别果蝇运动视觉的神经底物。然后,我们界定了已知电路元件和新电路元件的行为贡献。与之前研究的预期相反,我们发现对运动的定向反应至少由两条神经通路塑造。这些通路对不同的视觉特征敏感,在突触后立即分叉到光感受器,并与不同的行为输出相耦合。因此,即使是在最早的感觉处理阶段,对复杂刺激的行为反应也可以依赖于令人惊讶的神经专门化。
Motion vision is an ancient faculty, critical to many animals in a range of ethological contexts, the underlying algorithms of which provide central insights into neural computation. However, how motion cues guide behavior is poorly understood, as the neural circuits that implement these computations are largely unknown in any organism. We develop a systematic, forward genetic approach using high-throughput, quantitative behavioral analyses to identify the neural substrates of motion vision in Drosophila in unbiased fashion. We then delimit the behavioral contributions of both known and novel circuit elements. Contrary to expectation from previous studies, we find that orienting responses to motion are shaped by at least two neural pathways. These pathways are sensitive to different visual features, diverge immediately postsynaptic to photoreceptors, and are coupled to distinct behavioral outputs. Thus behavioral responses to complex stimuli can rely on surprising neural specialization from even the earliest sensory processing stages.
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