Skin-infiltrating, interleukin-22-producing T cells differentiate pediatric psoriasis from adult psoriasis.
Skin-infiltrating, interleukin-22-producing T cells differentiate pediatric psoriasis from adult psoriasis.
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DOI：
10.1016/j.jaad.2017.05.017
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发表时间：
2017-09
影响因子：
13.8
通讯作者：
Rosenblum, Michael D.
中科院分区：
文献类型：
--
作者：
Cordoro, Kelly M.;Hitraya-Low, Maria;Taravati, Keyon;Sandoval, Priscila Munoz;Kim, Esther;Sugarman, Jeffrey;Pauli, Mariela L.;Liao, Wilson;Rosenblum, Michael D.
Evidence from adult psoriasis studies implicates an imbalance between regulatory and effector T cells, particularly TH-17–producing T cells, in the pathogenesis of psoriasis. Little is known about the immunopathology of psoriasis in children. We sought to functionally characterize the inflammatory cell profiles of psoriatic plaques from pediatric patients and compare them with healthy, age-matched controls and adult psoriasis patients. Skin samples from pediatric psoriasis patients and healthy controls were analyzed by multiparameter flow cytometry to determine the dominant immune cell subsets present and cytokines produced. Lesional tissue from pediatric psoriasis patients had significantly increased interleukin (IL) 22 derived from CD4+ and CD8+ cells compared with the tissues from healthy pediatric controls and adult psoriasis patients. Tissue from pediatric psoriasis patients had significantly less elevation of IL-17 derived from CD4+ and CD8+ cells compared with the tissue from adult psoriasis patients. In contrast with the lesions from adult patients, lesional skin in pediatric patients with psoriasis did not have increases in regulatory T cells. This is a pilot study, thus the sample size is small. Significant differences in IL-17 and IL-22 expression were observed in the pediatric psoriasis patients compared with pediatric healthy controls and adult psoriasis patients. IL-22 might be relevant in the pathogenesis of pediatric psoriasis and represents a potential treatment target unique to pediatric psoriasis. Little is known about the pathophysiology of pediatric psoriasis. Increased expression of interleukin (IL) 22 relative to IL-17 was observed in pediatric compared with adult psoriasis patients. Elevated expression of IL-22, more so than IL-17, in pediatric compared to adult psoriatic plaques suggests an additional potential treatment target unique to pediatric psoriasis.
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影响因子：
1.5
作者：
Mercy K;Kwasny M;Cordoro KM;Menter A;Tom WL;Korman N;Belazarian L;Armstrong AW;Levy ML;Paller AS
通讯作者：
Paller AS
影响因子：
1.5
作者：
Raychaudhuri, SP;Gross, J
通讯作者：
Gross, J
DOI：
10.1111/j.1756-185x.2012.01813.x
发表时间：
2012-12-01
影响因子：
2.5
作者：
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通讯作者：
Kang, Seong Wook
影响因子：
4.6
作者：
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通讯作者：
Ciragil P
影响因子：
15.9
作者：
Rodriguez, Robert Sanchez;Pauli, Mariela L.;Rosenblum, Michael D.
通讯作者：
Rosenblum, Michael D.