HPV co-factors related to the development of cervical cancer: results from a population-based study in Costa Rica.
HPV co-factors related to the development of cervical cancer: results from a population-based study in Costa Rica.
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HPV辅助因子与宫颈癌的发展有关：哥斯达黎加的一项基于人群的研究结果。
DOI：
10.1054/bjoc.2001.1779
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发表时间：
2001-05-04
影响因子：
8.8
通讯作者：
Schiffman M
中科院分区：
文献类型：
--
作者：
Hildesheim A;Herrero R;Castle PE;Wacholder S;Bratti MC;Sherman ME;Lorincz AT;Burk RD;Morales J;Rodriguez AC;Helgesen K;Alfaro M;Hutchinson M;Balmaceda I;Greenberg M;Schiffman M
我们在哥斯达黎加的10077名妇女的人群队列中进行了一项流行病例对照研究，在人乳头瘤病毒（HPV）感染的妇女中检查了与高度鳞状上皮内病变（HSIL）和宫颈癌相关的因素。 我们将146名患有HPV阳性HSIL或癌症（HSIL/CA）的女性与843名没有HSIL/CA证据的HPV阳性女性进行了比较。受试者完成了一份风险因素问卷。我们评估了暴露与任何HPV阳性女性中HSIL/CA之间的相关性，并仅限于高危HPV类型阳性的女性。HSIL/CA的危险性随着活产数的增加而增加（P趋势= 0.04）。与非吸烟者相比，吸烟6支以上/天的女性HSIL/CA的RR为2.7（95% CI = 1.1-6.7）。目前使用屏障避孕药与HSIL/CA风险降低相关（RR = 0.39; 95%CI = 0.16-0.96）。性行为和自我报告的HPV以外的性传播疾病（STD）史与HSIL/CA无关。口服避孕药的使用与<3次妊娠妇女的HSIL/CA相关。在仅限于高危HPV类型阳性女性的分析中，效果相似。在高危型HPV阳性的女性中，44%的HSIL/CA可归因于多产（≥3次妊娠）和/或吸烟。在HPV阳性女性中，多产和吸烟是HSIL/CA的危险因素。口服避孕药的使用可能与HSIL/CA的妇女亚组。© 2001年癌症研究运动http://www.bjcancer.com
We examined factors associated with high-grade squamous intraepithelial lesions (HSIL) and cervical cancer among human papillomavirus (HPV)-infected women in a prevalent case–control study conducted within a population-based cohort of 10 077 women in Costa Rica. We compared 146 women with HPV-positive HSIL or cancer (HSIL/CA) against 843 HPV-positive women without evidence of HSIL/CA. Subjects completed a risk factor questionnaire. We evaluated the associations between exposures and HSIL/CA among women positive for any HPV and restricted to those positive for high-risk HPV types. Risk of HSIL/CA increased with increasing number of live births (Ptrend= 0.04). Women who smoked 6+ cigarettes/day had a RR for HSIL/CA of 2.7 (95% CI = 1.1–6.7) compared to non-smokers. Current use of barrier contraceptives was associated with a reduction in risk of HSIL/CA (RR = 0.39; 95% CI = 0.16–0.96). Sexual behaviour and a self-reported history of sexually transmitted diseases (STDs) other than HPV were not associated with HSIL/CA. Oral contraceptive use was associated with HSIL/CA among women with <3 pregnancies. Effects were similar in analysis restricted to women positive for high-risk HPV types. Among women positive for high-risk HPV types, 44% of HSIL/CA could be attributed to multiparity (≥3 pregnancies) and/or smoking. Among HPV-positive women, multiparity and smoking are risk factors for HSIL/CA. Oral contraceptive use may be associated with HSIL/CA in subgroups of women. © 2001 Cancer Research Campaign http://www.bjcancer.com
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影响因子：
5
作者：
BRINTON, LA;REEVES, WC;RAWLS, WE
通讯作者：
RAWLS, WE
DOI：
10.1016/s0002-9378(99)70602-2
发表时间：
1999-05-01
影响因子：
9.8
作者：
Fife, KH;Katz, BP;Brown, DR
通讯作者：
Brown, DR
DOI：
10.1016/0002-9378(95)90026-8
发表时间：
1995-03-01
影响因子：
9.8
作者：
COX, JT;LORINCZ, AT;KURMAN, RJ
通讯作者：
KURMAN, RJ
影响因子：
6.4
作者：
FIFE, KH;ROGERS, RE;ZWICKL, BW
通讯作者：
ZWICKL, BW
DOI：
10.1073/pnas.93.7.2930
发表时间：
1996-04-02
影响因子：
11.1
作者：
Arbeit, JM;Howley, PM;Hanahan, D
通讯作者：
Hanahan, D