Interaural attention modulates outer hair cell function.
Interaural attention modulates outer hair cell function.
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DOI：
10.1111/ejn.12746
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发表时间：
2014-12
期刊：
影响因子：
--
通讯作者：
Smith DW
中科院分区：
文献类型：
--
作者：
Srinivasan S;Keil A;Stratis K;Osborne AF;Cerwonka C;Wong J;Rieger BL;Polcz V;Smith DW
越来越多的证据表明，听觉注意任务可能通过皮质分离和内侧橄榄耳蜗区(MOC)传出通路调节耳蜗敏感度。在这里，我们研究了一个单独的传出通路，“未交叉”的MOC，它在功能上连接两只耳朵，在多大程度上调节耳间选择性注意。我们使用多模式目标检测任务，对单耳的失真产物耳声发射(DPOAE)和双耳呈现的初级耳声发射(DPOAE)进行了比较，在该任务中，参与者被指示报告简短目标事件(视觉变化、音调)的发生。在相同的物理刺激下比较了三种任务：(1)在记录DPOAE反应的耳朵中报告简短的音调；(2)在对侧未记录的耳朵中报告简短的音调；(3)报告注视时视觉栅格的短暂相移。观察到注意的影响是总体DPOAE轮廓水平的平行变化，与两种听觉注意条件相比，当被试忽略听觉刺激而关注视觉刺激时，DPOAEs的总体水平相对更高。重要的是，当注意到进行DPOAE记录的同侧耳朵时，DPOAE水平在统计上是最低的。这些数据证实了自上而下的机制，通过皮质分离和内侧传出通路，在多模式注意过程中调节耳蜗反应的观点。新的发现表明，照顾一只耳朵可以显著改变对侧无人看管的耳朵的生理反应，这可能是通过连接两只耳朵的未交叉的内侧橄榄耳蜗传出纤维来实现的。
Mounting evidence suggests that auditory attention tasks may modulate the sensitivity of the cochlea by way of the corticofugal and the medial olivocochlear (MOC) efferent pathways. Here, we studied the extent to which a separate efferent tract, the “uncrossed” MOC, which functionally connects the two ears, mediates inter-aural selective attention. We compared distortion product otoacoustic emissions (DPOAEs) in one ear to binaurally-presented primaries, using an intermodal target detection task in which participants were instructed to report the occurrence of brief target events (visual changes, tones). Three tasks were compared under identical physical stimulation: (1) report brief tones in the ear in which DPOAE responses were recorded; (2) report brief tones presented to the contralateral, non-recorded ear; (3) report brief phase shifts of a visual grating at fixation. Effects of attention were observed as parallel shifts in overall DPOAE contour level, with DPOAEs relatively higher in overall level when subjects ignored the auditory stimuli and attended to the visual stimulus, compared with both of the auditory-attending conditions. Importantly, DPOAE levels were statistically lowest when attention was directed to the ipsilateral ear in which the DPOAE recordings were made. These data corroborate notions that top-down mechanisms, via the corticofugal and medial efferent pathways, mediate cochlear responses during intermodal attention. New findings show attending to one ear can significantly alter the physiological response of the contralateral, unattended ear, likely through the uncrossed-medial olivocochlear efferent fibers connecting the two ears.
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影响因子：
2.4
作者：
GREENBERG, GZ;LARKIN, WD
通讯作者：
LARKIN, WD
影响因子：
3.7
作者：
Leon, Alex;Elgueda, Diego;Delano, Paul H.
通讯作者：
Delano, Paul H.
影响因子：
3.7
作者：
LUKAS, JH
通讯作者：
LUKAS, JH
影响因子：
3
作者：
MERIC, C;COLLET, L
通讯作者：
COLLET, L
DOI：
10.1097/moo.0b013e32833e05d6
发表时间：
2010-10
影响因子：
1.6
作者：
Guinan JJ Jr
通讯作者：
Guinan JJ Jr