Adjuvant Effect of Clarithromycin on Chemotherapy for Murine Lung Cancer
Adjuvant Effect of Clarithromycin on Chemotherapy for Murine Lung Cancer
复制标题
克拉霉素对小鼠肺癌化疗的辅助作用
作者：
K. Hamada;K. Mikasa;Y. Yunou;Takaaki Kurioka;T. Majima;N. Narita;E. Kita
克拉霉素 (CAM) 增加了接受化疗和/或放疗的不可切除的非小细胞肺癌患者的中位生存期 [Chemotherapy 1997;43:288–296]。本研究旨在确定单独的 CAM 是否对 Lewis 肺癌 (LLC) 具有抗肿瘤作用，并分析其对 LLC 接种的 C57BL/6 小鼠的佐剂作用的性质。 10 mg/kg/天的 CAM 延缓了皮下接种的 LLC 细胞的生长；因此，患有 LLC 的小鼠的平均存活时间增加了。静脉注射 LLC 细胞后，这种治疗方法还可有效减少肺部肿瘤结节的数量。当荷瘤小鼠在肿瘤接种后7天接受静脉注射硫酸长春地辛（7mg/kg）和顺铂（6mg/kg）时，化疗后7天开始时CAM治疗的化疗效果显着增强，但化疗后第二天开始时则不明显。延迟开始 CAM 治疗导致自然杀伤细胞活性和 CD8+ T 细胞细胞毒性增强，并增加产生干扰素 γ 的 T 细胞和产生白细胞介素 4 的 T 细胞的数量。这些发现表明，CAM 本身可以表现出抗肿瘤作用，并且还可以在从化疗引起的免疫抑制中恢复的荷瘤小鼠中诱导辅助性 T 细胞亚群的均衡扩增。因此，CAM 可能是抗癌化疗中一种很有前途的辅助药物，并且应在基本癌症治疗后的某个时间间隔开始使用这种大环内酯类药物进行治疗。
Clarithromycin (CAM) increased the median survival of patients with unresectable non-small-cell lung cancer who had received chemotherapy and/or radiotherapy [Chemotherapy 1997;43:288–296]. The present study was performed to ascertain whether CAM alone exhibits an antitumor effect against Lewis lung carcinoma (LLC) and to analyze the nature of its adjuvant effect on LLC-inoculated C57BL/6 mice. CAM at 10 mg/kg/day retarded the growth of subcutaneously inoculated LLC cells; consequently, the mean survival time of mice with LLC increased. This treatment was also effective in reducing the number of tumor nodules in the lung after intravenous inoculation with LLC cells. When tumor-bearing mice received an intravenous injection of vindesine sulfate (7 mg/kg) and cisplatin (6 mg/kg) 7 days after tumor inoculation, the chemotherapeutic effect was significantly enhanced by CAM treatment when it started 7 days after chemotherapy, but not when it started the day after chemotherapy. The delayed initiation of CAM treatment resulted in the enhancement of natural killer cell activity and CD8+ T cell cytotoxicity and increased the number of interferon-γ-producing T cells and interleukin-4-producing T cells. These findings indicate that CAM can exhibit an antitumor effect by itself and also induce the well-balanced expansion of helper T cell subsets in tumor-bearing mice recovering from the immunosuppression caused by chemotherapy. CAM may therefore be a promising adjuvant drug in anticancer chemotherapy, and treatment with this macrolide should be initiated at some interval after basic cancer therapy.
影响因子：
2.2
作者：
T. Taguchi;J. Mcghee;R. Coffman;K. Beagley;J. Eldridge;K. Takatsu;H. Kiyono
通讯作者：
T. Taguchi;J. Mcghee;R. Coffman;K. Beagley;J. Eldridge;K. Takatsu;H. Kiyono
影响因子：
4.4
作者：
R. Essner;K. Rhoades;W. McBride;D. Morton;J. Economou
通讯作者：
R. Essner;K. Rhoades;W. McBride;D. Morton;J. Economou
淋巴毒素和免疫干扰素对正常和恶性淋巴细胞的不同抑制作用。
DOI：
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发表时间：
1985
期刊：
Lymphokine research
影响因子：
--
作者：
Powell,MB;Conta,BS;Horowitz,M;Ruddle,NH
通讯作者：
Ruddle,NH