Sex prevalence of major congenital anomalies in the United Kingdom: a national population-based study and international comparison meta-analysis.
Sex prevalence of major congenital anomalies in the United Kingdom: a national population-based study and international comparison meta-analysis.
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DOI：
10.1002/bdra.23218
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发表时间：
2014-02
影响因子：
--
通讯作者：
Fleming, Kate M.
中科院分区：
文献类型：
--
作者：
Sokal, Rachel;Tata, Laila J.;Fleming, Kate M.
本研究的目的是评估性别差异的主要先天性异常（CA）的诊断在全国人口样本，以检查社会人口和孕产妇因素对这些风险的影响，并进行荟萃分析，使用其他人口为基础的研究估计。我们在英国研究数据库中进行了一项基于人群的研究，该数据库前瞻性收集了包括1990年至2009年出生的儿童（n = 794，169）的初级保健数据（健康改善网络），并使用EUROCAT（欧洲先天性异常监测）分类确定了主要CA诊断。患病率比（PR）用于估计男性与女性相比任何CA、系统特异性亚组和特异性CA诊断的CA风险。在一个其医疗记录与母亲相关的儿童亚群中，我们评估了调整社会人口学和母亲因素对性别比值比的影响。将PR与先前发表的研究的指标合并。男性中任何CA的患病率为307/10，000（95% CI，302-313），女性中为243/10，000（95% CI，238-248）。总体而言，男性中任何CA的风险均高出26%（PR（男性：女性）1.26，95% CI，1.23-1.30），但特定诊断之间存在相当大的差异。在调整社会人口学和母亲因素后，任何特定CA的风险程度和方向没有改变。我们的PR与以前的研究高度一致。CA的总体风险在男性中高于女性，尽管这掩盖了特定诊断的实质性差异。社会人口和母亲因素似乎并不影响这些风险。出生缺陷研究（A部分）100：79-91，2014年。© 2014 Wiley Periodicals，Inc.
The aim of this study was to assess sex differences in major congenital anomaly (CA) diagnoses within a national population sample; to examine the influence of sociodemographic and maternal factors on these risks; and to conduct a meta-analysis using estimates from other population-based studies. We conducted a population-based study in a United Kingdom research database of prospectively collected primary care data (The Health Improvement Network) including children born 1990 to 2009 (n = 794,169) and identified major CA diagnoses using EUROCAT (European Surveillance of Congenital Anomalies) classification. Prevalence ratios (PR) were used to estimate the risk of CA in males compared with females for any CA, system-specific subgroups and specific CA diagnoses. In a subpopulation of children whose medical records were linked to their mothers', we assessed the effect of adjusting for sociodemographic and maternal factors on sex odds ratios. PRs were pooled with measures from previously published studies. The prevalence of any CA was 307/10,000 in males (95% CI, 302–313) and 243/10,000 in females (95% CI, 238–248). Overall the risk of any CA was 26% greater in males (PR (male: female) 1.26, 95% CI, 1.23–1.30) however there was considerable variation across specific diagnoses. The magnitude and direction of risk did not change for any specific CA upon adjustment for sociodemographic and maternal factors. Our PRs were highly consistent with those from previous studies. The overall risk of CA is greater in males than females, although this masked substantial variation by specific diagnoses. Sociodemographic and maternal factors do not appear to affect these risks. Birth Defects Research (Part A) 100:79–91, 2014. © 2014 Wiley Periodicals, Inc.
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影响因子：
6.7
作者：
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通讯作者：
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影响因子：
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DOI：
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