Alpha 2-adrenoceptor modulation of nociception in rat spinal cord: location, effects and interactions with morphine.
Alpha 2-adrenoceptor modulation of nociception in rat spinal cord: location, effects and interactions with morphine.
复制标题
大鼠脊髓伤害感受的α2-肾上腺素受体调节：位置、作用以及与吗啡的相互作用。
DOI：
10.1016/0014-2999(87)90430-4
复制
发表时间：
1987
影响因子：
5
通讯作者：
Anthony H. Dickenson
中科院分区：
文献类型：
--
作者：
A. F. Sullivan;M. Dashwood;Anthony H. Dickenson
研究了单独鞘内注射可乐定和鞘内注射吗啡之前鞘内注射可乐定对氟烷麻醉大鼠背角电诱发Aβ和C纤维活性的影响。可乐定以剂量依赖性方式降低C纤维诱发的活动，最大抑制52%，萝芙木碱和育亨宾可逆转该抑制，但纳洛酮不起作用。高剂量可乐定对A纤维诱发的活动也产生小的抑制作用。可乐定增强鞘内吗啡对电诱发的C纤维活动的抑制作用，但不增强A纤维活动。此外，用选择性配体体外放射自显影法研究了大鼠腰髓连续切片中α2肾上腺素受体和阿片受体结合位点的位置，结果表明阿片受体和α2受体类型均存在于同一动物背角的同一浅层。结果表明，α2肾上腺素能受体和阿片受体在大鼠脊髓伤害性信息传递的调节中存在相互作用。
The effects of intrathecal clonidine alone and prior to intrathecal morphine were studied on electrically evoked Aβ and C fibre activity in the dorsal horn of the halothane-anaesthetised rat. Clonidine reduced C fibre-evoked activity in a dose-dependent manner, to a maximum 52% inhibition which was reversed by rauwolscine and yohimbine but not naloxone. High dose of clonidine also produced small inhibitions of A fibre-evoked activity. Clonidine potentiated the inhibitory action of intrathecal morphine on electrically evoked C fibre activity but not A fibre activity. In addition, the location of α2-adrenoceptor and opiate binding sites in consecutive sections of rat lumbar cord was investigated using in vitro autoradiography with selective ligands, and it was demonstrated that both opiate andα2-receptor types are present within the same superficial layers of the dorsal horn of the same animal. The results indicate thatα2-adrenoceptors and opiate receptors can interact in the modulation of nociceptive transmission in rat spinal cord.
DOI：
10.1146/annurev.pa.25.040185.002245
发表时间：
1985
影响因子：
12.5
作者：
T. Yaksh;R. Noueihed
通讯作者：
T. Yaksh;R. Noueihed
鞘内吗啡耐受：使用鞘内可乐定、DADLE 和脑室内吗啡。
影响因子：
8.8
作者：
Coombs,DW;Saunders,RL;Lachance,D;Savage,S;Ragnarsson,TS;Jensen,LE
通讯作者：
Jensen,LE