Bacterial biomechanics-From individual behaviors to biofilm and the gut flora.

Bacterial biomechanics-From individual behaviors to biofilm and the gut flora.
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DOI:
10.1063/5.0026953
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发表时间:
2020-12
期刊:
影响因子:
6
通讯作者:
Kikuchi K
Kikuchi K
中科院分区:
工程技术2区
文献类型:
--
作者:
Ishikawa T;Omori T;Kikuchi K

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细菌栖息在各种各样的地方,在环境和健康中发挥着重要作用。在过去的十年中,我们对细菌生物力学的理解有了显著的提高,并揭示了生物力学在微生物生物学中起着重要作用。所获得的知识使得能够研究复杂的现象,例如生物膜形成和肠道植物群的动态。自下而上的战略,即,从细胞到宏观,有助于理解宏观细菌现象。在这篇综述中,我们首先介绍了单个细菌在散装液体和表面上的生物力学,作为复杂现象的基础。接下来介绍简单环境中细菌的集体行为。然后,我们介绍了生物膜生物力学的最新进展,其中粘附力和流动环境起着至关重要的作用。我们还审查运输现象在肠道和肠道植物群的动力学,专注于在斑马鱼。最后,我们提供了该领域的未来前景的概述。
Bacteria inhabit a variety of locations and play important roles in the environment and health. Our understanding of bacterial biomechanics has improved markedly in the last decade and has revealed that biomechanics play a significant role in microbial biology. The obtained knowledge has enabled investigation of complex phenomena, such as biofilm formation and the dynamics of the gut flora. A bottom-up strategy, i.e., from the cellular to the macroscale, facilitates understanding of macroscopic bacterial phenomena. In this Review, we first cover the biomechanics of individual bacteria in the bulk liquid and on surfaces as the base of complex phenomena. The collective behaviors of bacteria in simple environments are next introduced. We then introduce recent advances in biofilm biomechanics, in which adhesion force and the flow environment play crucial roles. We also review transport phenomena in the intestine and the dynamics of the gut flora, focusing on that in zebrafish. Finally, we provide an overview of the future prospects for the field.
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