Engineering the Extracellular Matrix to Model the Evolving Tumor Microenvironment.
Engineering the Extracellular Matrix to Model the Evolving Tumor Microenvironment.
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DOI：
10.1016/j.isci.2020.101742
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发表时间：
2020-11-20
期刊：
影响因子：
5.8
通讯作者：
Kreeger PK
中科院分区：
文献类型：
--
作者：
Micek HM;Visetsouk MR;Masters KS;Kreeger PK
Clinical evidence supports a role for the extracellular matrix (ECM) in cancer risk and prognosis across multiple tumor types, and numerous studies have demonstrated that individual ECM components impact key hallmarks of tumor progression (e.g., proliferation, migration, angiogenesis). However, the ECM is a complex network of fibrillar proteins, glycoproteins, and proteoglycans that undergoes dramatic changes in composition and organization during tumor development. In this review, we will highlight how engineering approaches can be used to examine the impact of changes in tissue architecture, ECM composition (i.e., identity and levels of individual ECM components), and cellular- and tissue-level mechanics on tumor progression. In addition, we will discuss recently developed methods to model the ECM that have not yet been applied to the study of cancer. The extracellular matrix (ECM) is dramatically altered during cancer progression Engineering methods can model the resulting changes in tissue architecture in vitro Natural and synthetic biomaterials mimic changes in ECM composition and mechanics Fiber-based and dynamic materials not yet used to study tumor ECM are highlighted Tissue Engineering; Cancer
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影响因子：
3.5
作者：
Charrier EE;Pogoda K;Li R;Wells RG;Janmey PA
通讯作者：
Janmey PA
影响因子：
6
作者：
Conklin, Matthew W.;Eickhoff, Jens C.;Keely, Patricia J.
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DOI：
10.1039/c4ib00218k
发表时间：
2015-02
期刊：
Integrative biology : quantitative biosciences from nano to macro
影响因子：
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作者：
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DOI：
10.1039/c5ib00040h
发表时间：
2015-10
期刊：
Integrative biology : quantitative biosciences from nano to macro
影响因子：
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作者：
Acerbi I;Cassereau L;Dean I;Shi Q;Au A;Park C;Chen YY;Liphardt J;Hwang ES;Weaver VM
通讯作者：
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影响因子：
41.2
作者：
Baker BM;Trappmann B;Wang WY;Sakar MS;Kim IL;Shenoy VB;Burdick JA;Chen CS
通讯作者：
Chen CS