Elasticity-dependent response of malignant cells to viscous dissipation.
Elasticity-dependent response of malignant cells to viscous dissipation.
复制标题
恶性肿瘤细胞对粘性耗散的弹性依赖性反应。
DOI：
10.1007/s10237-020-01374-9
复制
发表时间：
2021-03
影响因子：
3.5
通讯作者：
Janmey PA
中科院分区：
文献类型：
--
作者：
Charrier EE;Pogoda K;Li R;Wells RG;Janmey PA
The stiffness of the cellular environment controls malignant cell phenotype and proliferation. However, the effect of viscous dissipation on these parameters has not yet been investigated, in part due to the lack of in vitro cell substrates reproducing the mechanical properties of normal tissues and tumors. In this article, we use a newly reported viscoelastic polyacrylamide gel cell substrate, and we characterize the impact of viscous dissipation on three malignant cell lines: DU145 and PC3 derived from prostate and LN229 from brain. The spreading, motility and proliferation rates of these cells were analyzed on 1 kPa and 5 kPa elastic and viscoelastic gels. Surprisingly, the effect of substrate viscous dissipation on cell behavior depended on substrate stiffness for the three cell types tested. We conclude that viscoelasticity controls the spreading, proliferation and migration of malignant cells in vitro. These results highlight the critical role of viscous dissipation in the phenotype and proliferation of malignant cells, especially in stiff tumor environments.
登录
查看更多内容
影响因子：
24.3
作者：
Correia, Ana Luisa;Bissell, Mina J.
通讯作者：
Bissell, Mina J.
影响因子：
16.6
作者：
Chaudhuri O;Gu L;Darnell M;Klumpers D;Bencherif SA;Weaver JC;Huebsch N;Mooney DJ
通讯作者：
Mooney DJ
影响因子：
16.6
作者：
Bangasser BL;Shamsan GA;Chan CE;Opoku KN;Tüzel E;Schlichtmann BW;Kasim JA;Fuller BJ;McCullough BR;Rosenfeld SS;Odde DJ
通讯作者：
Odde DJ
用声辐射力量化肝脏粘弹性：大鼠模型肝纤维化的研究
影响因子：
2.9
作者：
Chen, Xin;Shen, Yuanyuan;Chen, Siping
通讯作者：
Chen, Siping
影响因子：
3.3
作者：
Leight JL;Wozniak MA;Chen S;Lynch ML;Chen CS
通讯作者：
Chen CS