Assessment of odor hedonic perception: the Sniffin' sticks parosmia test (SSParoT).

Assessment of odor hedonic perception: the Sniffin' sticks parosmia test (SSParoT).
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DOI:
10.1038/s41598-020-74967-0
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发表时间:
2020-10-22
期刊:
影响因子:
4.6
通讯作者:
Renner B
Renner B
中科院分区:
综合性期刊3区
文献类型:
--
作者:
Liu DT;Welge-Lüssen A;Besser G;Mueller CA;Renner B

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定性嗅觉功能障碍的特征在于扭曲的气味感知,并可能对受影响个体的生活质量产生深远影响。嗅觉倒错和幻嗅觉代表了定性损害的两个主要亚组,目前仅根据患者病史进行诊断。我们开发了一种基于嗅棒识别子测试的气味来测量定性嗅觉功能的测试方法。新开发的测试被称为Sniffin' Sticks嗅觉异常测试(SSParoT)。SSParoT使用两种相反价的气味(愉快和不愉快)的享乐估计来评估享乐范围(HR)和享乐方向(HD),这代表了定性的嗅觉感知。HR被定义为两种相反价的气味之间的可感知的享乐距离,而HD用作气味的整体享乐感知的指标。这项多中心研究在四个连续实验中共招募了162名嗅觉正常的受试者。聚类分析被用来分组气味从16个项目的嗅棒识别测试和24个额外的气味到集群具有不同的享乐属性。十一气味对被认为是适合估计的HR和HD。分析表明,所有气味对之间的协议测试,重测会议。SSparoT可能成为一个有价值的工具,以评估定性嗅觉功能的健康和疾病。
Qualitative olfactory dysfunction is characterized as distorted odor perception and can have a profound effect on quality of life of affected individuals. Parosmia and phantosmia represent the two main subgroups of qualitative impairment and are currently diagnosed based on patient history only. We have developed a test method which measures qualitative olfactory function based on the odors of the Sniffin’ Sticks Identification subtest. The newly developed test is called Sniffin’ Sticks Parosmia Test (SSParoT). SSParoT uses hedonic estimates of two oppositely valenced odors (pleasant and unpleasant) to assess hedonic range (HR) and hedonic direction (HD), which represent qualitative olfactory perception. HR is defined as the perceivable hedonic distance between two oppositely valenced odors, while HD serves as an indicator for overall hedonic perception of odors. This multicenter study enrolled a total of 162 normosmic subjects in four consecutive experiments. Cluster analysis was used to group odors from the 16-item Sniffin’ Sticks Identification test and 24-additional odors into clusters with distinct hedonic properties. Eleven odor pairs were found to be suitable for estimation of HR and HD. Analysis showed agreement between test–retest sessions for all odor pairs. SSparoT might emerge as a valuable tool to assess qualitative olfactory function in health and disease.
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