Brain Energy Metabolism in Ischemic Stroke: Effects of Smoking and Diabetes.
Brain Energy Metabolism in Ischemic Stroke: Effects of Smoking and Diabetes.
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DOI：
10.3390/ijms23158512
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发表时间：
2022-07-31
影响因子：
5.6
通讯作者：
中科院分区：
文献类型：
--
作者：
适当调节大脑中的能量代谢对于在生理和不同病理生理条件下维持大脑活动至关重要。缺血性卒中具有复杂的病理生理学，包括脑能量代谢过程的扰动，其可导致脑损伤和卒中结局恶化。吸烟和糖尿病是缺血性卒中的常见危险因素和共病条件，也与脑能量代谢的破坏有关。同时存在这些条件可能会进一步改变大脑中的能量代谢，导致缺血性卒中事件后临床预后不良。在这篇综述中，我们讨论了吸烟和/或糖尿病对脑葡萄糖利用和线粒体能量代谢的可能影响，当同时存在时，可能会加剧缺血性脑的能量代谢。需要更多的研究来调查吸烟和/或糖尿病存在下缺血性卒中的脑葡萄糖利用和线粒体氧化代谢，这将提供对这些共病条件的病理生理学的进一步见解，并促进治疗干预措施的发展。
Proper regulation of energy metabolism in the brain is crucial for maintaining brain activity in physiological and different pathophysiological conditions. Ischemic stroke has a complex pathophysiology which includes perturbations in the brain energy metabolism processes which can contribute to worsening of brain injury and stroke outcome. Smoking and diabetes are common risk factors and comorbid conditions for ischemic stroke which have also been associated with disruptions in brain energy metabolism. Simultaneous presence of these conditions may further alter energy metabolism in the brain leading to a poor clinical prognosis after an ischemic stroke event. In this review, we discuss the possible effects of smoking and/or diabetes on brain glucose utilization and mitochondrial energy metabolism which, when present concurrently, may exacerbate energy metabolism in the ischemic brain. More research is needed to investigate brain glucose utilization and mitochondrial oxidative metabolism in ischemic stroke in the presence of smoking and/or diabetes, which would provide further insights on the pathophysiology of these comorbid conditions and facilitate the development of therapeutic interventions.
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影响因子：
6.3
作者：
Andersen, Jens V.;Christensen, Sofie K.;Waagepetersen, Helle S.
通讯作者：
Waagepetersen, Helle S.
影响因子：
2.5
作者：
Angamo, Eskedar Ayele;Roesner, Joerg;Heinemann, Uwe
通讯作者：
Heinemann, Uwe
影响因子：
4.4
作者：
Bruening, Cesar A.;Prigol, Marina;Nogueira, Cristina W.
通讯作者：
Nogueira, Cristina W.
影响因子：
3.4
作者：
Molnar M;Lennmyr F
通讯作者：
Lennmyr F
影响因子：
5.2
作者：
Bonita, R;Duncan, J;Beaglehole, R
通讯作者：
Beaglehole, R