Neuroprotection by S-PBN in hyperglycemic ischemic brain injury in rats.
Neuroprotection by S-PBN in hyperglycemic ischemic brain injury in rats.
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DOI：
10.3109/03009734.2010.498592
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发表时间：
2010-08
影响因子：
3.4
通讯作者：
Lennmyr F
中科院分区：
文献类型：
--
作者：
Molnar M;Lennmyr F
高血糖可通过多种机制加重局灶性脑缺血损伤。一种这样的机制是氧化应激，涉及活性氧和氮物种(RON)的产生。硝酸根可减轻各种脑损伤模型中的氧化应激。2-磺基苯基-N-叔丁基硝酸钠(S-PBN)可用于实验性脑损伤，对实验性脑损伤有神经保护作用。我们推测S-PBN对高血糖局灶性脑缺血可能具有神经保护作用。大鼠经腹腔注射葡萄糖(2g/kg)造成高血糖，然后造成大脑中动脉短暂性闭塞(MCAO)90min。他们被随机分为S PBN156 mg/kg和生理盐水静脉给药两组。1d后进行Bederson和四氮唑蓝染色的神经功能测试。S-PBN治疗后第1天的Bederson评分(1.3±0.8比2.7±0.48)和斜面评分(74.5%±4.6比66%±8.3，P<0.0 5)均有改善，但不能缩小梗塞面积。生理数据在不同组之间没有差异。S PBN可改善高血糖缺血性脑损伤大鼠短期存活(1天)的神经功能状态。这一效应似乎主要与缩小梗塞面积无关。
Hyperglycemia exacerbates focal ischemic brain damage supposedly through various mechanisms. One such mechanism is oxidative stress involving reactive oxygen and nitrogen species (RONS) production. Nitrones attenuate oxidative stress in various models of brain injury. Sodium 2-sulfophenyl-N-tert-butyl nitrone (S-PBN) can be administered experimentally and has been shown to be neuroprotective in experimental brain trauma. We hypothesized that S-PBN might be neuroprotective in hyperglycemic focal cerebral ischemia. Rats were made hyperglycemic by an intraperitoneal bolus injection of glucose (2 g/kg) and then subjected to 90 min transient middle cerebral artery occlusion (MCAO). They were randomized to a therapeutic regime of S-PBN (156 mg/kg) or saline given intravenously. Neurological testing according to Bederson and tetrazolium red staining were performed after 1 day. S-PBN improved the neurological performance at day 1 both in Bederson score (1.3 ± 0.8 versus 2.7 ± 0.48) and on the inclined plane (74.5% ± 4.6 (S-PBN) versus 66% ± 8.3 (control), P < 0.05) but did not reduce the infarct size. Physiological data did not differ between groups. S-PBN may improve neurological performance at short-term survival (1 day) in the present model of hyperglycemic-ischemic brain injury in rats. This effect appeared not to be primarily related to reduced infarct size.
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影响因子：
4.2
作者：
Bemeur, Chantal;Ste-Marie, Line;Montgomery, Jane
通讯作者：
Montgomery, Jane
影响因子：
--
作者：
Hoshiyama, M;Li, B;Oite, T
通讯作者：
Oite, T
影响因子：
8.3
作者：
BEDERSON, JB;PITTS, LH;BARTKOWSKI, H
通讯作者：
BARTKOWSKI, H
DOI：
10.1152/ajpheart.1997.272.6.h2859
发表时间：
1997-06-01
影响因子：
4.8
作者：
Ginsberg, MD;Zhao, W;Busto, R
通讯作者：
Busto, R
DOI：
10.1097/00004647-199802000-00011
发表时间：
1998-02-01
影响因子：
6.3
作者：
Peters, O;Back, T;Dirnagl, U
通讯作者：
Dirnagl, U