The observation and execution of actions share motor and somatosensory voxels in all tested subjects: single-subject analyses of unsmoothed fMRI data.
The observation and execution of actions share motor and somatosensory voxels in all tested subjects: single-subject analyses of unsmoothed fMRI data.
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DOI：
10.1093/cercor/bhn181
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发表时间：
2009-06
期刊：
影响因子：
--
通讯作者：
Keysers C
中科院分区：
文献类型：
--
作者：
Gazzola V;Keysers C
许多镜像神经元系统（MNS）的神经影像学研究检查大脑中的某些体素是否在动作观察和执行之间共享（共享体素，sVx）。不幸的是，在标准组分析中发现sVx并不能保证sVx存在于个体受试者中。使用非平滑，单受试者分析，我们表明sVx可以可靠地发现在所有16个调查的参与者。除了在猴的腹侧前运动区（BA 6/44）和下顶叶皮层（PF区）发现镜像神经元（MN）外，sVx还在背侧前运动区、辅助运动区、中扣带回、体感区（BA 3、BA 2和OP 1）、上级顶叶、中颞叶皮层和小脑中可靠地观察到。对于运动前区、躯体感觉区和顶叶区，sVx在左半球较多。在观察手部动作时，初级运动皮层的手部表征显示BOLD减少，这可能是为了防止不必要的明显模仿。本研究提供了一个更详细的描述sVx的位置和可靠性，并提出了一个模型，扩展了MNS的原始想法，包括正向和反向内部模型和运动和感觉模拟，区分MNS从一个更一般的概念sVx。
Many neuroimaging studies of the mirror neuron system (MNS) examine if certain voxels in the brain are shared between action observation and execution (shared voxels, sVx). Unfortunately, finding sVx in standard group analyses is not a guarantee that sVx exist in individual subjects. Using unsmoothed, single-subject analyses we show sVx can be reliably found in all 16 investigated participants. Beside the ventral premotor (BA6/44) and inferior parietal cortex (area PF) where mirror neurons (MNs) have been found in monkeys, sVx were reliably observed in dorsal premotor, supplementary motor, middle cingulate, somatosensory (BA3, BA2, and OP1), superior parietal, middle temporal cortex and cerebellum. For the premotor, somatosensory and parietal areas, sVx were more numerous in the left hemisphere. The hand representation of the primary motor cortex showed a reduced BOLD during hand action observation, possibly preventing undesired overt imitation. This study provides a more detailed description of the location and reliability of sVx and proposes a model that extends the original idea of the MNS to include forward and inverse internal models and motor and sensory simulation, distinguishing the MNS from a more general concept of sVx.
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