Impact of hydrogen gas inhalation during therapeutic hypothermia on cerebral hemodynamics and oxygenation in the asphyxiated piglet.
Impact of hydrogen gas inhalation during therapeutic hypothermia on cerebral hemodynamics and oxygenation in the asphyxiated piglet.
复制标题
DOI：
10.1038/s41598-023-28274-z
复制
发表时间：
2023-01-28
影响因子：
4.6
通讯作者：
中科院分区：
文献类型：
--
作者：
我们先前报道了联合氢气（H2）通气治疗和治疗性低温（TH）的神经保护潜力，通过评估5天新生儿缺氧缺血性（HI）脑病仔猪的短期神经功能结局和组织学结果。然而，氢气对脑循环和氧代谢以及预后的影响尚不清楚。在这里，我们使用近红外时间分辨光谱比较组合H2气体通气和TH与TH单独。将仔猪分为三组：常温HI损伤（NT，n = 10）、低温HI损伤（TH，33.5 ± 0.5 ℃，n = 8）和低温加H2通气HI损伤（TH + H2，2.1- 2.7%，n = 8）。伤后24 h给予H2通气和TH，记录脑血容量（CBV）和脑血红蛋白氧饱和度（ScO 2）。TH + H2组CBV在损伤后24 h显著高于其他各组。TH + H2组的ScO 2在损伤后24 h内显著低于NT组。总之，联合H2气体通气和TH增加CBV和降低ScO 2，这可能反映了脑血流量升高，以满足更大的氧气需求的存活神经元，与TH单独相比。
We previously reported the neuroprotective potential of combined hydrogen (H2) gas ventilation therapy and therapeutic hypothermia (TH) by assessing the short-term neurological outcomes and histological findings of 5-day neonatal hypoxic-ischemic (HI) encephalopathy piglets. However, the effects of H2 gas on cerebral circulation and oxygen metabolism and on prognosis were unknown. Here, we used near-infrared time-resolved spectroscopy to compare combined H2 gas ventilation and TH with TH alone. Piglets were divided into three groups: HI insult with normothermia (NT, n = 10), HI insult with hypothermia (TH, 33.5 ± 0.5 °C, n = 8), and HI insult with hypothermia plus H2 ventilation (TH + H2, 2.1–2.7%, n = 8). H2 ventilation and TH were administered and the cerebral blood volume (CBV) and cerebral hemoglobin oxygen saturation (ScO2) were recorded for 24 h after the insult. CBV was significantly higher at 24 h after the insult in the TH + H2 group than in the other groups. ScO2 was significantly lower throughout the 24 h after the insult in the TH + H2 group than in the NT group. In conclusion, combined H2 gas ventilation and TH increased CBV and decreased ScO2, which may reflect elevated cerebral blood flow to meet greater oxygen demand for the surviving neurons, compared with TH alone.
登录
查看更多内容
DOI：
10.1056/nejmoa1112066
发表时间：
2012-05-31
期刊：
The New England journal of medicine
影响因子：
--
作者：
Shankaran S;Pappas A;McDonald SA;Vohr BR;Hintz SR;Yolton K;Gustafson KE;Leach TM;Green C;Bara R;Petrie Huitema CM;Ehrenkranz RA;Tyson JE;Das A;Hammond J;Peralta-Carcelen M;Evans PW;Heyne RJ;Wilson-Costello DE;Vaucher YE;Bauer CR;Dusick AM;Adams-Chapman I;Goldstein RF;Guillet R;Papile LA;Higgins RD;Eunice Kennedy Shriver NICHD Neonatal Research Network
通讯作者：
Eunice Kennedy Shriver NICHD Neonatal Research Network
影响因子：
168.9
作者：
Gluckman, PD;Wyatt, JS;Gunn, AJ
通讯作者：
Gunn, AJ
DOI：
10.1016/j.bbrc.2008.05.165
发表时间：
2008-08-15
影响因子：
3.1
作者：
Hayashida, Kentaro;Sano, Motoaki;Fukuda, Keiichi
通讯作者：
Fukuda, Keiichi
影响因子：
5.7
作者：
Wintermark, P.;Hansen, A.;Soul, J. S.
通讯作者：
Soul, J. S.
影响因子：
15.9
作者：
Gunn, AJ;Gunn, TR;Gluckman, PD
通讯作者：
Gluckman, PD