Can Inhibin B Reflect Ovarian Reserve of Healthy Reproductive Age Women Effectively?
Can Inhibin B Reflect Ovarian Reserve of Healthy Reproductive Age Women Effectively?
复制标题
抑制素B能否有效反映健康育龄女性的卵巢储备情况？
DOI：
10.3389/fendo.2021.626534
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发表时间：
2021
影响因子：
5.2
通讯作者：
Wang S
中科院分区：
文献类型：
--
作者：
Wen J;Huang K;Du X;Zhang H;Ding T;Zhang C;Ma W;Zhong Y;Qu W;Liu Y;Li Z;Deng S;Luo A;Jin Y;Zhang J;Wang S
Objective The reference range and potential value of inhibin B are still unclear and controversial. This study aimed to define the variation trend of inhibin B in healthy women with age and explore its value in the reflection of ovarian reserve. Methods A total of 2524 healthy reproductive age women from eight medical institutes nationwide were recruited. The variation tendency of inhibin B with age was primarily established in the first group of 948 women and validated in another 605. We evaluated the relationship between inhibin B and classic ovarian reserve and function markers. The potency of inhibin B in predicting AFC <5-7 was also estimated and compared with FSH. Results The nomogram showed that serum levels of inhibin B rapidly decreased after the age of 40. Inhibin B was positively correlated with AMH (R = 0.57, P < 0.001), AFC (R = 0.34, P < 0.001) and testosterone (R = 0.10, P = 0.002), and negatively correlated with FSH (R = -0.41, P < 0.001) and LH (R = -0.20, P < 0.001) and FSH/LH (R=-0.18, P < 0.001), while no correlation was found with PRL. Unexpectedly, Inhibin B (AUC = 0.74, P < 0.001 for the establishment population; AUC = 0.78, P < 0.001 for the validation population) had a slightly higher value than FSH (AUC = 0.71, P < 0.001 for the establishment population; AUC = 0.72, P < 0.001 for the validation population) in diagnosing AFC <5-7. Conclusions For healthy reproductive age women, the decline of inhibin B can reflect decreased ovarian reserve effectively, having a good consistency with AMH and AFC. More importantly, inhibin B had an advantage in predicting AFC <5-7 compared with FSH, which suggested the potential of inhibin B in predicting ovarian response. These results will be helpful to the clinical application of inhibin B in the evaluation of female ovarian reserve and the assessment of their reproductive capacity. Trial registration: http://clinicaltrials.gov; NCT02294500.
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影响因子：
5.2
作者：
Esteves SC;Roque M;Bedoschi GM;Conforti A;Humaidan P;Alviggi C
通讯作者：
Alviggi C
影响因子：
3.1
作者：
Fried, G;Remaeus, K;Tally, M
通讯作者：
Tally, M
影响因子：
2
作者：
Fiçicioglu, C;Kutlu, T;Mulayim, B
通讯作者：
Mulayim, B
影响因子：
39.3
作者：
Reference Values for Arterial Stiffness' Collaboration
通讯作者：
Reference Values for Arterial Stiffness' Collaboration
影响因子：
45.3
作者：
Behringer, Karolin;Mueller, Horst;Borchmann, Peter
通讯作者：
Borchmann, Peter