Determinants of pulse wave velocity in healthy people and in the presence of cardiovascular risk factors: 'establishing normal and reference values'.
Determinants of pulse wave velocity in healthy people and in the presence of cardiovascular risk factors: 'establishing normal and reference values'.
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DOI：
10.1093/eurheartj/ehq165
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发表时间：
2010-10
影响因子：
39.3
通讯作者：
Reference Values for Arterial Stiffness' Collaboration
中科院分区：
文献类型：
--
作者：
Reference Values for Arterial Stiffness' Collaboration
颈动脉-股动脉脉搏波速度(PWV)是直接测量主动脉僵硬程度的指标，在心血管风险评估中变得越来越重要。由于缺乏参考价值，它作为临床患者评估的常规工具的应用受到了阻碍。本研究的目的是建立基于大量欧洲人口的PWV的参考值和正常值。我们收集了来自8个欧洲国家13个不同中心的16867名受试者和患者的数据，其中测量了PWV和基本临床参数。其中11092例无显性心血管疾病、非糖尿病且未经降压或降脂药物治疗，构成参考值人群，其中血压最佳/正常的亚组(n=1455)为正常值人群。在数据汇集之前，使用已建立的转换公式将PWV值转换为通用标准。受试者按年龄、十岁进行分类，并根据BP类别进一步细分。脉搏波速度随年龄和血压类别的增加而增加；血压类别越高，脉搏波速度的增加越明显，而血压越高，年龄越大，脉搏波速度的增加越重要。描述了PWV随年龄和BP类别的分布，并建立了PWV的参考值。正常值是基于在没有额外心血管危险因素的非高血压亚群中观察到的PWV值而提出的。这项研究首次建立了PWV的参考值和正常值，在标准化了不同PWV测量方法的结果后，结合了相当大的欧洲人群。
Carotid–femoral pulse wave velocity (PWV), a direct measure of aortic stiffness, has become increasingly important for total cardiovascular (CV) risk estimation. Its application as a routine tool for clinical patient evaluation has been hampered by the absence of reference values. The aim of the present study is to establish reference and normal values for PWV based on a large European population. We gathered data from 16 867 subjects and patients from 13 different centres across eight European countries, in which PWV and basic clinical parameters were measured. Of these, 11 092 individuals were free from overt CV disease, non-diabetic and untreated by either anti-hypertensive or lipid-lowering drugs and constituted the reference value population, of which the subset with optimal/normal blood pressures (BPs) (n = 1455) is the normal value population. Prior to data pooling, PWV values were converted to a common standard using established conversion formulae. Subjects were categorized by age decade and further subdivided according to BP categories. Pulse wave velocity increased with age and BP category; the increase with age being more pronounced for higher BP categories and the increase with BP being more important for older subjects. The distribution of PWV with age and BP category is described and reference values for PWV are established. Normal values are proposed based on the PWV values observed in the non-hypertensive subpopulation who had no additional CV risk factors. The present study is the first to establish reference and normal values for PWV, combining a sizeable European population after standardizing results for different methods of PWV measurement.
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影响因子：
37.8
作者：
Sutton-Tyrrell, K;Najjar, SS;Newman, A
通讯作者：
Newman, A
影响因子：
14
作者：
Sugawara, Jun;Hayashi, Koichiro;Tanaka, Hirofumi
通讯作者：
Tanaka, Hirofumi
影响因子：
37.8
作者：
Blacher, J;Guerin, AP;London, GM
通讯作者：
London, GM
影响因子：
4.9
作者：
Alecu, Cosmin;Labat, Carlos;Benetos, Athanase
通讯作者：
Benetos, Athanase
影响因子：
2.7
作者：
Salvi, P.;Magnani, E.;Benetos, A.
通讯作者：
Benetos, A.