Investigation of the effect of directional (off-axis) illumination on the reflectivity of retina layers in mice using swept-source optical coherence tomography

Investigation of the effect of directional (off-axis) illumination on the reflectivity of retina layers in mice using swept-source optical coherence tomography
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使用扫源光学相干断层扫描研究定向(离轴)照明对小鼠视网膜层反射率的影响

DOI:
10.1117/12.2288739
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发表时间:
2018
期刊:
Ophthalmic Technologies XXVIII; 104742B
影响因子:
--
通讯作者:
Manns, Fabrice
Manns, Fabrice
中科院分区:
--
文献类型:
--
作者:
Meleppat, Ratheesh K.;Zhang, Pengfei;Wahl, Daniel J.;Jian, Yifan;Manna, Suman K.;Sarunic, Marinko V.;Pugh, Edward N.;Zawadzki, Robert J.;Ju, Myeong Jin;Manns, Fabrice

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OCT临床成像中已报告了人类视网膜亨利纤维层和感光带的可见性随照明方向性的变化。这些是分别由于纤维组织取向和光感受器的波导特性而引起的背散射变化的直接结果。在这里,我们报告的初步研究结果的视网膜图像的影响与OCT的照明方向性在小鼠视网膜。使用扫频光源光学相干断层扫描系统在体内对BALB/c和WT有色小鼠的视网膜层的反射率进行定量评估。测量并比较视网膜不同外层的背散射信号强度。
Changes in visibility of the Henle fiber layer and photoreceptor bands of the human retina with illumination directionality have been reported in OCT clinical imaging. These are a direct consequence of the changes in back scattering due to fibrous tissue orientation and to waveguiding properties of the photoreceptors respectively. Here we report the preliminary results of a study on the effects of retinal images acquired with OCT of illumination directionality in the mouse retina. The quantitative assessment of the reflectivity of retinal layers of a BALB/c and WT pigmented mice was performed in-vivo using a swept-source optical coherence tomography system. The intensities of backscattered signals from different outer retinal layers were measured and compared.
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