Adaptive optics OCT using 1060nm swept source and dual deformable lenses for human retinal imaging
Adaptive optics OCT using 1060nm swept source and dual deformable lenses for human retinal imaging
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使用 1060nm 扫频光源和双变形透镜进行人类视网膜成像的自适应光学 OCT
DOI：
10.1117/12.2213534
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发表时间：
2016
影响因子：
11.8
通讯作者：
M. Sarunic
中科院分区：
文献类型：
--
作者：
Y. Jian;Sujin Lee;M. Cua;Dongkai Miao;S. Bonora;R. Zawadzki;M. Sarunic
自适应光学的概念已经应用到生物成像和显微镜的进步。特别是，AO也非常成功地应用于视网膜的细胞分辨率成像，可以使用泛光眼底摄影，扫描激光眼科检查（SLO）和光学相干断层扫描（OCT）来可视化视网膜外层的特征马赛克图案。尽管活体图像的质量很高，但AO成像在临床环境中的应用有限。AO提供的高分辨率是以有限的视野和专用设备为代价的。一个典型的自适应光学成像系统的实现导致了一个相对较大和复杂的光学设置。波前测量通常使用哈特曼-夏克波前传感器（HS-WFS）放置在与眼睛瞳孔光学共轭的成像平面上。可变形的镜子也被放置在一个共轭平面上，将波前修正传递给瞳孔。由于HS-WFS对背反射的敏感性，成像系统通常由球面反射镜构成。在这个项目中，我们提出了一种新的自适应光学OCT视网膜成像系统，该系统具有很大的潜力，可以克服许多与临床环境集成的障碍。我们详细描述了一种基于紧凑型透镜的无波前传感器自适应光学（WSAO） 1060nm扫描源OCT人体视网膜成像系统的实现，该系统具有双可变形透镜，并展示了从研究志愿者体内获得的视网膜图像。
Adaptive optics concepts have been applied to the advancement of biological imaging and microscopy. In particular, AO has also been very successfully applied to cellular resolution imaging of the retina, enabling visualization of the characteristic mosaic patterns of the outer retinal layers using flood illumination fundus photography, Scanning Laser Ophthalmoscopy (SLO), and Optical Coherence Tomography (OCT). Despite the high quality of the in vivo images, there has been a limited uptake of AO imaging into the clinical environment. The high resolution afforded by AO comes at the price of limited field of view and specialized equipment. The implementation of a typical adaptive optics imaging system results in a relatively large and complex optical setup. The wavefront measurement is commonly performed using a Hartmann-Shack Wavefront Sensor (HS-WFS) placed at an image plane that is optically conjugated to the eye’s pupil. The deformable mirror is also placed at a conjugate plane, relaying the wavefront corrections to the pupil. Due to the sensitivity of the HS-WFS to back-reflections, the imaging system is commonly constructed from spherical mirrors. In this project, we present a novel adaptive optics OCT retinal imaging system with significant potential to overcome many of the barriers to integration with a clinical environment. We describe in detail the implementation of a compact lens based wavefront sensorless adaptive optics (WSAO) 1060nm swept source OCT human retinal imaging system with dual deformable lenses, and present retinal images acquired in vivo from research volunteers.
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用于小鼠体内视网膜成像的波前无传感器自适应光学荧光生物显微镜。
影响因子：
3.4
作者：
Wahl,DanielJ;Jian,Yifan;Bonora,Stefano;Zawadzki,RobertJ;Sarunic,MarinkoV
通讯作者：
Sarunic,MarinkoV
使用波前无传感器自适应光学光学相干断层扫描对人类感光细胞镶嵌进行体内成像。
影响因子：
3.4
作者：
Wong,KevinSK;Jian,Yifan;Cua,Michelle;Bonora,Stefano;Zawadzki,RobertJ;Sarunic,MarinkoV
通讯作者：
Sarunic,MarinkoV
影响因子：
3.8
作者：
Bonora, Stefano;Jian, Yifan;Sarunic, Marinko V.
通讯作者：
Sarunic, Marinko V.
影响因子：
3.6
作者：
Huber, Robert;Adler, Desmond C.;Fujimoto, James G.
通讯作者：
Fujimoto, James G.
DOI：
10.1364/josaa.24.001250
发表时间：
2007-05-01
影响因子：
1.9
作者：
Delori, Francois C.;Webb, Robert H.;Sliney, David H.
通讯作者：
Sliney, David H.