IP-10 and MCP-1 as biomarkers associated with disease severity of COVID-19.
IP-10 and MCP-1 as biomarkers associated with disease severity of COVID-19.
复制标题
IP-10 和 MCP-1 作为与 COVID-19 疾病严重程度相关的生物标志物。
DOI：
10.1186/s10020-020-00230-x
复制
发表时间：
2020-10-29
期刊：
影响因子：
--
通讯作者：
Zhang S
中科院分区：
文献类型：
--
作者：
Chen Y;Wang J;Liu C;Su L;Zhang D;Fan J;Yang Y;Xiao M;Xie J;Xu Y;Li Y;Zhang S
COVID-19是由严重急性呼吸道综合征-冠状病毒2型（SARS-CoV-2）引起的病毒性呼吸道疾病。患有这种疾病的患者可能更容易发生静脉或动脉血栓形成，因为参与其中的许多因素被激活，包括炎症，血小板活化和内皮功能障碍。干扰素γ诱导蛋白-10（IP-10）、单核细胞趋化蛋白-1（MCP-1）和巨噬细胞炎性蛋白1-α（MIP 1 α）是与血栓形成相关的细胞因子。因此，本研究重点关注COVID-19中的这三个指标，希望找到与患者预后相关的生物标志物。这是一项回顾性单中心研究，纳入了从中国武汉同济医院ICU招募的74名重症和危重症COVID-19患者。患者分为重症患者和危重症患者两组。采用酶联免疫吸附法（ELISA）检测两组患者血清IP-10、MCP-1和MIP 1 α水平。回顾性分析了COVID-19患者的临床症状、实验室检查结果和结局。危重症患者血清IP-10和MCP-1水平显著高于重症患者（P < 0.001）。动态变化分析显示，预后不良患者的MIP 1 α明显升高。由于所选患者均为重症或危重症，因此未观察到生存和死亡之间的显著差异。IP-10和MCP-1是与COVID-19疾病严重程度相关的生物标志物，可能与COVID-19患者的死亡风险相关。
COVID-19 is a viral respiratory disease caused by the severe acute respiratory syndrome-Coronavirus type 2 (SARS-CoV-2). Patients with this disease may be more prone to venous or arterial thrombosis because of the activation of many factors involved in it, including inflammation, platelet activation and endothelial dysfunction. Interferon gamma inducible protein-10 (IP-10), monocyte chemoattractant protein-1 (MCP-1) and macrophage inflammatory protein 1-alpha (MIP1α) are cytokines related to thrombosis. Therefore, this study focused on these three indicators in COVID-19, with the hope to find biomarkers that are associated with patients’ outcome. This is a retrospective single-center study involving 74 severe and critically ill COVID-19 patients recruited from the ICU department of the Tongji Hospital in Wuhan, China. The patients were divided into two groups: severe patients and critically ill patients. The serum IP-10, MCP-1 and MIP1α level in both groups was detected using the enzyme-linked immunosorbent assay (ELISA) kit. The clinical symptoms, laboratory test results, and the outcome of COVID-19 patients were retrospectively analyzed. The serum IP-10 and MCP-1 level in critically ill patients was significantly higher than that in severe patients (P < 0.001). However, no statistical difference in MIP1α between the two groups was found. The analysis of dynamic changes showed that these indicators remarkably increased in patients with poor prognosis. Since the selected patients were severe or critically ill, no significant difference was observed between survival and death. IP-10 and MCP-1 are biomarkers associated with the severity of COVID-19 disease and can be related to the risk of death in COVID-19 patients.
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DOI：
10.1007/978-3-030-36667-4_2
发表时间：
2020-01-01
期刊：
TUMOR MICROENVIRONMENT: THE ROLE OF CHEMOKINES, PT A
影响因子：
--
作者：
Ntanasis-Stathopoulos, Ioannis;Fotiou, Despoina;Terpos, Evangelos
通讯作者：
Terpos, Evangelos
影响因子：
168.9
作者：
Huang, Chaolin;Wang, Yeming;Cao, Bin
通讯作者：
Cao, Bin
影响因子：
4.3
作者：
LI, YS;SHYY, YJ;KOLATTUKUDY, PE
通讯作者：
KOLATTUKUDY, PE
影响因子：
20.1
作者：
Bodnar, RJ;Yates, CC;Wells, A
通讯作者：
Wells, A
影响因子：
39
作者：
Wu, Chaomin;Chen, Xiaoyan;Song, Yuanlin
通讯作者：
Song, Yuanlin