Stabilisierung von Nanopartikeln in Blasensäulen – Einfluss von Schaumschichthöhe und pH‐Wert

Stabilisierung von Nanopartikeln in Blasensäulen – Einfluss von Schaumschichthöhe und pH‐Wert
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气泡塔中纳米颗粒的稳定性 - 泡沫层高度和 pH 值的影响

DOI:
10.1002/cite.201100202
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发表时间:
2012
影响因子:
1.9
通讯作者:
D. Koch
D. Koch
中科院分区:
工程技术4区
文献类型:
--
作者:
A.P. Weber;S. Pieper;D. Koch

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有机药物纳米颗粒可以通过使用表面活性剂溶液的超临界溶液到水溶液中的快速膨胀(RESSAS)稳定在纳米悬浮液中。采用模型鼓泡塔研究了泡沫高度、pH值等相关系统参数对沉淀和稳定效果的影响。事实证明,已经在低的高度,在上升的气泡和泡沫中的沉积过程的组合导致纳米颗粒的高分离效率,其被表面活性剂很好地稳定。pH值影响泡沫性质,从而影响分离效率。
Organic drug nanoparticles may be stabilized in nanosupensions by Rapid Expansion of Supercritical Solutions into Aqueous Solutions (RESSAS) using surfactant solutions. A model bubble column was used in the present work in order to study the influence of relevant system parameters, such as foam height and pH value, on the deposition and stabilization efficiency. It turned out that, already at low heights, the combination of deposition processes in the rising bubbles and in the foam results in high separation efficiency for nanoparticles, which are well stabilized by the surfactants. The pH value influences the foam properties and consequently the separation efficiency.
DOI: 10.1080/02786829508965310
发表时间: 1995
影响因子: 5.2
作者:
S. Mertes;F. Schröder;A. Wiedensohler
通讯作者: S. Mertes;F. Schröder;A. Wiedensohler