The impact of SARS-CoV-2 on the cystic fibrosis foundation therapeutics development network.
The impact of SARS-CoV-2 on the cystic fibrosis foundation therapeutics development network.
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DOI：
10.1016/j.jcf.2020.12.007
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发表时间：
2021-03
期刊：
影响因子：
--
通讯作者：
Nichols DP
中科院分区：
文献类型：
--
作者：
Pearson K;Mayer-Hamblett N;Goss CH;Retsch-Bogart GZ;VanDalfsen JM;Burks P;Rosenbluth D;Clancy JP;Hoffman A;Nichols DP
严重急性呼吸综合征冠状病毒（SARS-CoV-2）全球大流行严重影响了囊性纤维化基金会治疗发展网络（CFF TDN）内的CF临床研究。一项研究电子数据采集（REDCap）调查被开发并发送到网络站点，以监测和了解对研究团队、正在进行和预期的临床研究以及具体的临床和研究程序的影响。主要研究结果表明，早期影响参与者的入组、研究团队的稳定性以及肺量测定和痰诱导等程序。随着整个TDN的研究活动开始恢复，这些趋势在几个月内稳步改善。虽然SARS-CoV-2带来了重大挑战，但它也凸显了扩大CF研究的新机遇，更多地关注研究中心以外的数据收集，并增加远程参与的机会。
The Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2) global pandemic significantly impacted CF clinical research within the Cystic Fibrosis Foundation Therapeutics Development Network (CFF TDN). A Research Electronic Data Capture (REDCap) survey was developed and sent to network sites to monitor and understand the impact on research teams, ongoing and anticipated clinical research, and specific clinical and research procedures. Key findings indicated an early impact on participant enrollment, research team stability, and procedures such as spirometry and sputum induction. These trends steadily improved over the months as research activities began to recover across the TDN. While SARS-CoV-2 created a significant challenge it also highlights new opportunities to expand CF research with greater focus on data collection outside of research centers and increased access for remote participation.
DOI：
10.1016/j.jcf.2020.10.003
发表时间：
2020-11
期刊：
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society
影响因子：
--
作者：
McClenaghan E;Cosgriff R;Brownlee K;Ahern S;Burgel PR;Byrnes CA;Colombo C;Corvol H;Cheng SY;Daneau G;Elbert A;Faro A;Goss CH;Gulmans V;Gutierrez H;de Monestrol I;Jung A;Justus LN;Kashirskaya N;Marshall BC;McKone E;Middleton PG;Mondejar-Lopez P;Pastor-Vivero MD;Padoan R;Rizvi S;Ruseckaite R;Salvatore M;Stephenson AL;Filho LVRDS;Melo J;Zampoli M;Carr SB;Global Registry Harmonization Group
通讯作者：
Global Registry Harmonization Group
影响因子：
5.2
作者：
Cosgriff, Rebecca;Ahern, Susannah;Carr, Siobhan B.
通讯作者：
Carr, Siobhan B.