The global impact of SARS-CoV-2 in 181 people with cystic fibrosis.
The global impact of SARS-CoV-2 in 181 people with cystic fibrosis.
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DOI：
10.1016/j.jcf.2020.10.003
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发表时间：
2020-11
期刊：
影响因子：
--
通讯作者：
Global Registry Harmonization Group
中科院分区：
文献类型：
--
作者：
McClenaghan E;Cosgriff R;Brownlee K;Ahern S;Burgel PR;Byrnes CA;Colombo C;Corvol H;Cheng SY;Daneau G;Elbert A;Faro A;Goss CH;Gulmans V;Gutierrez H;de Monestrol I;Jung A;Justus LN;Kashirskaya N;Marshall BC;McKone E;Middleton PG;Mondejar-Lopez P;Pastor-Vivero MD;Padoan R;Rizvi S;Ruseckaite R;Salvatore M;Stephenson AL;Filho LVRDS;Melo J;Zampoli M;Carr SB;Global Registry Harmonization Group
随着SARS-CoV-2大流行的日益严重，我们需要更好地了解其对特定患者群体（如囊性纤维化（CF）患者）的影响。我们报告了来自19个国家的181名CF患者（32名移植后患者），他们在2020年6月13日之前被诊断为SARS-CoV-2。SARS-CoV-2感染似乎表现出与普通人群相似的结果谱，有11人入院接受重症监护（7人移植后），7人死亡（3人移植后）。更严重的临床病程可能与年龄较大、CF相关糖尿病、感染前一年肺功能较低以及接受过器官移植有关。虽然这一大型队列的结果比最初担心的总体情况要好，但可能是由于CF人群与其他慢性疾病相比相对年轻的保护作用，SARS-CoV-2并不是该患者群体中所有人的良性疾病。
With the growing SARS-CoV-2 pandemic, we need to better understand its impact in specific patient groups like those with Cystic Fibrosis (CF). We report on 181 people with CF (32 post-transplant) from 19 countries diagnosed with SARS-CoV-2 prior to 13 June 2020. Infection with SARS-CoV-2 appears to exhibit a similar spectrum of outcomes to that seen in the general population, with 11 people admitted to intensive care (7 post-transplant), and 7 deaths (3 post-transplant). A more severe clinical course may be associated with older age, CF-related diabetes, lower lung function in the year prior to infection, and having received an organ transplant. Whilst outcomes in this large cohort are better than initially feared overall, possibly due to a protective effect of the relatively younger age of the CF population compared to other chronic conditions, SARS-CoV-2 is not a benign disease for all people in this patient group.
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