Symptom Clustering Patterns and Population Characteristics of COVID-19 Based on Text Clustering Method.
Symptom Clustering Patterns and Population Characteristics of COVID-19 Based on Text Clustering Method.
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DOI：
10.3389/fpubh.2022.795734
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发表时间：
2022
影响因子：
5.2
通讯作者：
Zhang T
中科院分区：
文献类型：
--
作者：
Cheng X;Wan H;Yuan H;Zhou L;Xiao C;Mao S;Li Z;Hu F;Yang C;Zhu W;Zhou J;Zhang T
2019冠状病毒病（COVID-19）的单一临床症状的描述已被广泛报道。然而，症状关联的证据仍然有限。我们寻求探索COVID-19的潜在症状聚集模式和高频症状组合，以提高人们对这种疾病的认识。在这项回顾性队列研究中，共招募了1，067例COVID-19病例。症状聚类模式首先探讨了文本聚类方法。然后，应用多项逻辑回归来揭示不同症状组的群体特征。此外，分析了症状发作与首次访视之间的时间间隔，以考虑时间间隔延长对症状进展的影响。基于文本聚类，将症状归纳为四组。第一组：无明显症状;第二组：主要为发热和/或干咳;第3组：主要为上呼吸道感染症状;第4组：主要为心肺、全身和/或胃肠道症状。除第1组无明显症状外，最常见的症状组合仅为发热（64例，47.8%），其次为单纯干咳第2组（42例，31.3%）;仅咳痰（21例，19.8%），其次为咳痰伴发热第3组10例，占9.4%;第4组疲乏伴发热12例，占4.2%，其次为头痛伴发热11例，占3.8%。45-64岁的人比65岁或以上的人更容易出现第4组症状（比值比[OR] = 2.66，95% CI：1.21-5.85），同时有更长的时间间隔。COVID-19的症状可以分为四个具有不同症状组合的聚类组。第4组症状（即，主要是心肺、全身和/或胃肠道症状）在COVID-19中的发生频率高于流感。这种区别有助于加深对这种疾病的理解。从医疗延误的角度来看，中年人就诊间隔时间较长，是一个值得关注的群体。
Descriptions of single clinical symptoms of coronavirus disease 2019 (COVID-19) have been widely reported. However, evidence of symptoms associations was still limited. We sought to explore the potential symptom clustering patterns and high-frequency symptom combinations of COVID-19 to enhance the understanding of people of this disease. In this retrospective cohort study, a total of 1,067 COVID-19 cases were enrolled. Symptom clustering patterns were first explored by a text clustering method. Then, a multinomial logistic regression was applied to reveal the population characteristics of different symptom groups. In addition, time intervals between symptoms onset and the first visit were analyzed to consider the effect of time interval extension on the progression of symptoms. Based on text clustering, the symptoms were summarized into four groups. Group 1: no-obvious symptoms; Group 2: mainly fever and/or dry cough; Group 3: mainly upper respiratory tract infection symptoms; Group 4: mainly cardiopulmonary, systemic, and/or gastrointestinal symptoms. Apart from Group 1 with no obvious symptoms, the most frequent symptom combinations were fever only (64 cases, 47.8%), followed by dry cough only (42 cases, 31.3%) in Group 2; expectoration only (21 cases, 19.8%), followed by expectoration complicated with fever (10 cases, 9.4%) in Group 3; fatigue complicated with fever (12 cases, 4.2%), followed by headache complicated with fever was also high (11 cases, 3.8%) in Group 4. People aged 45–64 years were more likely to have symptoms of Group 4 than those aged 65 years or older (odds ratio [OR] = 2.66, 95% CI: 1.21–5.85) and at the same time had longer time intervals. Symptoms of COVID-19 could be divided into four clustering groups with different symptom combinations. The Group 4 symptoms (i.e., mainly cardiopulmonary, systemic, and/or gastrointestinal symptoms) happened more frequently in COVID-19 than in influenza. This distinction could help deepen the understanding of this disease. The middle-aged people have a longer time interval for medical visit and was a group that deserve more attention, from the perspective of medical delays.
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影响因子：
8.3
作者：
Cobb NL;Sathe NA;Duan KI;Seitz KP;Thau MR;Sung CC;Morrell ED;Mikacenic C;Kim HN;Liles WC;Luks AM;Town J;Pipavath S;Wurfel MM;Hough CL;West TE;Bhatraju PK
通讯作者：
Bhatraju PK
DOI：
10.1016/s0140-6736(21)00183-5
发表时间：
2021-02-06
期刊：
Lancet (London, England)
影响因子：
--
作者：
Sabino EC;Buss LF;Carvalho MPS;Prete CA Jr;Crispim MAE;Fraiji NA;Pereira RHM;Parag KV;da Silva Peixoto P;Kraemer MUG;Oikawa MK;Salomon T;Cucunuba ZM;Castro MC;de Souza Santos AA;Nascimento VH;Pereira HS;Ferguson NM;Pybus OG;Kucharski A;Busch MP;Dye C;Faria NR
通讯作者：
Faria NR
影响因子：
2.2
作者：
Papadopoulos VP;Koutroulos MV;Zikoudi DG;Bakola SA;Avramidou P;Touzlatzi N;Filippou DK
通讯作者：
Filippou DK
DOI：
10.1631/jzus.b2000479
发表时间：
2021-02-15
期刊：
Journal of Zhejiang University. Science. B
影响因子：
--
作者：
Bai Y;Tao X
通讯作者：
Tao X
影响因子：
9.2
作者：
Lv Z;Lv S
通讯作者：
Lv S