Clinical characteristics and analysis of risk factors for disease progression of COVID-19: A retrospective Cohort Study.
Clinical characteristics and analysis of risk factors for disease progression of COVID-19: A retrospective Cohort Study.
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DOI：
10.7150/ijbs.50654
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发表时间：
2021
影响因子：
9.2
通讯作者：
Lv S
中科院分区：
文献类型：
--
作者：
Lv Z;Lv S
目的：自二零一九年十二月起，2019冠状病毒病（COVID 19）从中国武汉爆发至全球。本研究采用回顾性队列研究的方法，总结了武汉江岸方舱医院COVID-19患者的临床特征，并探讨了影响病程的危险因素。方法：回顾性分析409例COVID-19患者的临床特点。我们描述了每例患者的临床特征和出院时间或转移时间的分布。然后，我们进行了单变量和多变量考克斯回归分析，以确定从非重度进展到重度COVID-19或死亡的潜在风险因素。结果：所有患者的中位病程为23天（IQR 19-28）。主要症状为发热（95.6%）、咳嗽（74.3%）、乏力（21.5%）等，合并症主要为高血压（30.6%）、糖尿病（17.6%）和心脏病（12.5%）。单因素考克斯回归分析显示，年龄、症状数、合并高血压、心脏病和肺部疾病与疾病进展相关。多因素考克斯回归分析显示，老年（HR：7.294; 95%CI：1.442-36.888; P = 0.016），合并高血压（HR：2.230; 95%CI：1.090-4.562; P = 0.028）和心脏病（HR：2.650; 95%CI：1.079-6.510; P = 0.034）是COVID-19进展的独立危险因素。结论：患者年龄、合并高血压和心脏病是COVID-19进展的独立危险因素。对于有这些风险因素的患者应提高警惕。
Objective: Since December 2019, an outbreak of coronavirus disease 2019 (COVID 19) has been experienced from Wuhan, China to the world. A retrospective cohort study was conducted to summarize the clinical characteristics of patients with COVID-19 and to explore the risk factors affecting the disease duration in Jiangan Fangcang shelter hospital, Wuhan, China. Methods: Clinical characteristics of 409 patients with COVID-19 were retrospectively analyzed. We describe the clinical characteristics and distribution of discharge time or transfer time for each patient. Then we performed univariate and multivariate Cox regression analysis to identify potential risk factors for progression from non-severe to severe COVID-19 or death. Results: The median disease duration of all patients was 23 days (IQR 19-28). The main symptoms of the patient were fever (95.6%), cough (74.3%), tiredness (21.5%), and so on. Comorbidities mainly included hypertension (30.6%) diabetes (17.6%) and heart disease (12.5%). The univariate Cox regression analysis showed that old age, number of symptoms, the combination of hypertension, heart disease and pulmonary disease were associated with the progression of disease. The multivariate Cox regression analysis showed that old age (HR: 7.294; 95% CI: 1.442-36.888; P = 0.016), the combination of hypertension (HR: 2.230; 95% CI: 1.090-4.562; P = 0.028) and heart disease (HR: 2.650; 95% CI: 1.079-6.510; P = 0.034) were independent risk factors for progression of COVID-19. Conclusions: The age of the patient, the combination of hypertension and heart disease were independent risk factors for the progression of COVID-19. Cautions should be raised for patients with these risk factors.
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影响因子：
64.5
作者：
Dimitrov DS
通讯作者：
Dimitrov DS
影响因子：
5.2
作者：
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通讯作者：
Penninger JM
DOI：
10.26355/eurrev_202003_20711
发表时间：
2020-03-01
影响因子：
3.3
作者：
Zheng, F.;Tang, W.;Zhou, Z-G
通讯作者：
Zhou, Z-G