Genome-wide association studies: contribution of genomics to understanding blood pressure and essential hypertension.
Genome-wide association studies: contribution of genomics to understanding blood pressure and essential hypertension.
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DOI：
10.1007/s11906-009-0086-6
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发表时间：
2010-02
影响因子：
5.6
通讯作者：
Ehret, Georg B.
中科院分区：
文献类型：
--
作者：
Ehret, Georg B.
现在，当代基因组工具允许数十万变体的快速和可靠的基因分型，并允许对整个人类基因组的共同变异性进行公正的询问。这些技术进步一直是对复杂遗传特征基因的近期研究的基础，血压和高血压的结果尤其令人感兴趣。复杂的遗传性状血压和高血压的病理生理尚不清楚。基本高血压的遗传力很高，可以通过找到相关基因来获得见解。当前的全基因组关联研究（GWAS）已经确定了通常与血压或本质高血压相关的基因或附近的10至20个基因座。当更大，更精致的研究可用时，将发现更重要的变体。本文简要介绍了GWAS，并总结了目前的血压和高血压发现。
Contemporary genomic tools now allow the fast and reliable genotyping of hundreds of thousands of variants and permit an unbiased interrogation of the common variability across the human genome. These technical advances have been the basis of numerous recent investigations of genes underlying complex genetic traits, and the results for blood pressure and hypertension have been of particular interest. The pathophysiology of the complex genetic trait blood pressure and hypertension is unclear. The heritability of essential hypertension is high and insights can be gained by finding associated genes. Current genome-wide association studies (GWAS) have identified 10 to 20 loci in or near genes that generally were not expected to be associated with blood pressure or essential hypertension; more significant variants will be discovered when even larger and more refined studies become available. This article gives a short introduction to GWAS and summarizes the current findings for blood pressure and hypertension.
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影响因子：
64.8
作者：
Frazer, Kelly A.;Ballinger, Dennis G.;Cox, David R.;Hinds, David A.;Stuve, Laura L.;Gibbs, Richard A.;Belmont, John W.;Boudreau, Andrew;Hardenbol, Paul;Leal, Suzanne M.;Pasternak, Shiran;Wheeler, David A.;Willis, Thomas D.;Yu, Fuli;Yang, Huanming;Zeng, Changqing;Gao, Yang;Hu, Haoran;Hu, Weitao;Li, Chaohua;Lin, Wei;Liu, Siqi;Pan, Hao;Tang, Xiaoli;Wang, Jian;Wang, Wei;Yu, Jun;Zhang, Bo;Zhang, Qingrun;Zhao, Hongbin;Zhao, Hui;Zhou, Jun;Gabriel, Stacey B.;Barry, Rachel;Blumenstiel, Brendan;Camargo, Amy;Defelice, Matthew;Faggart, Maura;Goyette, Mary;Gupta, Supriya;Moore, Jamie;Nguyen, Huy;Onofrio, Robert C.;Parkin, Melissa;Roy, Jessica;Stahl, Erich;Winchester, Ellen;Ziaugra, Liuda;Altshuler, David;Shen, Yan;Yao, Zhijian;Huang, Wei;Chu, Xun;He, Yungang;Jin, Li;Liu, Yangfan;Shen, Yayun;Sun, Weiwei;Wang, Haifeng;Wang, Yi;Wang, Ying;Xiong, Xiaoyan;Xu, Liang;Waye, Mary M. Y.;Tsui, Stephen K. W.;Wong, J. Tze-Fei;Galver, Luana M.;Fan, Jian-Bing;Gunderson, Kevin;Murray, Sarah S.;Oliphant, Arnold R.;Chee, Mark S.;Montpetit, Alexandre;Chagnon, Fanny;Ferretti, Vincent;Leboeuf, Martin;Olivier, Jean-Franccois;Phillips, Michael S.;Roumy, Stephanie;Sallee, Clementine;Verner, Andrei;Hudson, Thomas J.;Kwok, Pui-Yan;Cai, Dongmei;Koboldt, Daniel C.;Miller, Raymond D.;Pawlikowska, Ludmila;Taillon-Miller, Patricia;Xiao, Ming;Tsui, Lap-Chee;Mak, William;Song, You Qiang;Tam, Paul K. H.;Nakamura, Yusuke;Kawaguchi, Takahisa;Kitamoto, Takuya;Morizono, Takashi;Nagashima, Atsushi;Ohnishi, Yozo;Sekine, Akihiro;Tanaka, Toshihiro;Tsunoda, Tatsuhiko;Deloukas, Panos;Bird, Christine P.;Delgado, Marcos;Dermitzakis, Emmanouil T.;Gwilliam, Rhian;Hunt, Sarah;Morrison, Jonathan;Powell, Don;Stranger, Barbara E.;Whittaker, Pamela;Bentley, David R.;Daly, Mark J.;de Bakker, Paul I. W.;Barrett, Jeff;Chretien, Yves R.;Maller, Julian;McCarroll, Steve;Patterson, Nick;Pe'er, Itsik;Price, Alkes;Purcell, Shaun;Richter, Daniel J.;Sabeti, Pardis;Saxena, Richa;Schaffner, Stephen F.;Sham, Pak C.;Varilly, Patrick;Altshuler, David;Stein, Lincoln D.;Krishnan, Lalitha;Smith, Albert Vernon;Tello-Ruiz, Marcela K.;Thorisson, Gudmundur A.;Chakravarti, Aravinda;Chen, Peter E.;Cutler, David J.;Kashuk, Carl S.;Lin, Shin;Abecasis, Goncalo R.;Guan, Weihua;Li, Yun;Munro, Heather M.;Qin, Zhaohui Steve;Thomas, Daryl J.;McVean, Gilean;Auton, Adam;Bottolo, Leonardo;Cardin, Niall;Eyheramendy, Susana;Freeman, Colin;Marchini, Jonathan;Myers, Simon;Spencer, Chris;Stephens, Matthew;Donnelly, Peter;Cardon, Lon R.;Clarke, Geraldine;Evans, David M.;Morris, Andrew P.;Weir, Bruce S.;Tsunoda, Tatsuhiko;Johnson, Todd A.;Mullikin, James C.;Sherry, Stephen T.;Feolo, Michael;Skol, Andrew
通讯作者：
Skol, Andrew
影响因子：
9.8
作者：
Göring, HHH;Terwilliger, JD;Blangero, J
通讯作者：
Blangero, J
影响因子：
30.8
作者：
Arking, Dan E.;Pfeufer, Arne;Chakravarti, Aravinda
通讯作者：
Chakravarti, Aravinda
影响因子：
30.8
作者：
Levy, Daniel;Ehret, Georg B.;Rice, Kenneth;Verwoert, Germaine C.;Launer, Lenore J.;Dehghan, Abbas;Glazer, Nicole L.;Morrison, Alanna C.;Johnson, Andrew D.;Aspelund, Thor;Aulchenko, Yurii;Lumley, Thomas;Koettgen, Anna;Vasan, Ramachandran S.;Rivadeneira, Fernando;Eiriksdottir, Gudny;Guo, Xiuqing;Arking, Dan E.;Mitchell, Gary F.;Mattace-Raso, Francesco U. S.;Smith, Albert V.;Taylor, Kent;Scharpf, Robert B.;Hwang, Shih-Jen;Sijbrands, Eric J. G.;Bis, Joshua;Harris, Tamara B.;Ganesh, Santhi K.;O'Donnell, Christopher J.;Hofman, Albert;Rotter, Jerome I.;Coresh, Josef;Benjamin, Emelia J.;Uitterlinden, Andre G.;Heiss, Gerardo;Fox, Caroline S.;Witteman, Jacqueline C. M.;Boerwinkle, Eric;Wang, Thomas J.;Gudnason, Vilmundur;Larson, Martin G.;Chakravarti, Aravinda;Psaty, Bruce M.;van Duijn, Cornelia M.
通讯作者：
van Duijn, Cornelia M.
影响因子：
--
作者：
Levy D;Larson MG;Benjamin EJ;Newton-Cheh C;Wang TJ;Hwang SJ;Vasan RS;Mitchell GF
通讯作者：
Mitchell GF