Interpreting the language of histone and DNA modifications.
Interpreting the language of histone and DNA modifications.
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DOI：
10.1016/j.bbagrm.2014.03.001
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发表时间：
2014-08
影响因子：
4.7
通讯作者：
Strahl, Brian D.
中科院分区：
文献类型：
--
作者：
Rothbart, Scott B.;Strahl, Brian D.
调节真核生物基因组的可及性和功能的主要机制是对DNA和组蛋白的共价修饰，其依赖性地将我们的遗传信息包装在每个细胞的细胞核内。十多年前正式假设，越来越清楚的是，组蛋白上的翻译后修饰（PTM）单独或组合作用以形成一种语言或“代码”，该语言或“代码”被专门的蛋白质读取以促进染色质中的下游功能。当时，人们对组蛋白PTM及其组合以及阅读和解释语言的蛋白质的复杂性水平认识不足。除了组蛋白PTM之外，新发现的可以招募特定效应蛋白的DNA修饰进一步提高了人们的认识，即组蛋白PTM在更广泛的表观遗传修饰语言中起作用，以协调与染色质相关的动态功能。在这里，我们强调了我们对表观遗传语言（包括组蛋白和DNA修饰）的理解的最新进展，并预示了未来的挑战，因为我们继续寻求破译染色质调控的基本机制。
A major mechanism regulating the accessibility and function of eukaryotic genomes are the covalent modifications to DNA and histone proteins that dependably package our genetic information inside the nucleus of every cell. Formally postulated over a decade ago, it is becoming increasingly clear that post-translational modifications (PTMs) on histones act singly and in combination to form a language or ‘code’ that is read by specialized proteins to facilitate downstream functions in chromatin. Underappreciated at the time was the level of complexity harbored both within histone PTMs and their combinations, as well as within the proteins that read and interpret the language. In addition to histone PTMs, newly-identified DNA modifications that can recruit specific effector proteins has raised further awareness that histone PTMs operate within a broader language of epigenetic modifications to orchestrate the dynamic functions associated with chromatin. Here, we highlight key recent advances in our understanding of the epigenetic language encompassing histone and DNA modifications and foreshadow challenges that lie ahead as we continue our quest to decipher the fundamental mechanisms of chromatin regulation.
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影响因子：
16
作者：
Blackledge NP;Zhou JC;Tolstorukov MY;Farcas AM;Park PJ;Klose RJ
通讯作者：
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新型组蛋白翻译后修饰的蛋白质组学表征。
影响因子：
3.9
作者：
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通讯作者：
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DOI：
10.1073/pnas.51.5.786
发表时间：
1964-01-01
影响因子：
11.1
作者：
ALLFREY, VG;FAULKNER, R;MIRSKY, AE
通讯作者：
MIRSKY, AE
影响因子：
56.9
作者：
Bostick, Magnolia;Kim, Jong Kyong;Jacobsen, Steven E.
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