Histone chaperones in nucleosome assembly and human disease.

Histone chaperones in nucleosome assembly and human disease.
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DOI:
10.1038/nsmb.2461
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发表时间:
2013-01
影响因子:
16.8
通讯作者:
Zhang, Zhiguo
Zhang, Zhiguo
中科院分区:
生物学1区
文献类型:
--
作者:
Burgess, Rebecca J.;Zhang, Zhiguo

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DNA 复制、DNA 修复和基因转录后的核小体组装对于维持基因组稳定性和表观遗传信息至关重要。核小体在组蛋白伴侣蛋白的帮助下通过复制偶联或复制独立途径组装。这些不同的核小体组装途径是如何调节的仍然相对不清楚。最近的研究深入了解了组蛋白伴侣调节核小体组装的机制和作用。核小体组装相关因素的改变或突变也与癌症和其他人类疾病有关。这篇综述强调了该领域的最新进展并概述了未来的挑战。
Nucleosome assembly following DNA replication, DNA repair and gene transcription is critical for the maintenance of genome stability and epigenetic information. Nucleosomes are assembled via replication-coupled or replication-independent pathways with the aid of histone chaperone proteins. How these different nucleosome assembly pathways are regulated remains relatively unclear. Recent studies have provided insight into the mechanisms and the roles of histone chaperones regulating nucleosome assembly. Alterations or mutations in factors involved in nucleosome assembly have also been implicated in cancer and other human diseases. This review highlights the recent progress and outlines future challenges in the field.
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