Stimuli sensitive polymers and self regulated drug delivery systems: a very partial review.
Stimuli sensitive polymers and self regulated drug delivery systems: a very partial review.
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DOI：
10.1016/j.jconrel.2014.06.035
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发表时间：
2014-09-28
期刊：
影响因子：
--
通讯作者：
Siegel RA
中科院分区：
文献类型：
--
作者：
Siegel RA
自从《控制释放杂志》创刊之初，人们就对能够按需释放药物的材料产生了相当大的兴趣。所谓的“刺激反应”和“智能”系统被设计成根据内源性或外源性的刺激，在不同的时间或在身体的不同部位输送药物。在过去的三十年里，沿着这些思路进行的研究取得了许多方向，每一代新的研究人员都发现了新的物理化学原理和化学原理，通过这些原理和化学原理可以改变材料的释放特性。任何单一的审查都不可能公正地对待所有这些方法。在本文中，我们作了一些一般性的观察，并给出了该领域的部分历史。对开环和闭环系统进行了讨论。特别强调的是刺激响应性水凝胶和能够重复响应的系统。有人认为，目前和在可预见的未来，最成功的是将生物传感和驱动(即药物输送)分开的系统，由人类和/或控制论操作者将两者联系起来。
Since the early days of the Journal of Controlled Release, there has been considerable interest in materials that can release drug on an “on-demand” basis. So called “stimuli-responsive” and “intelligent” systems have been designed to deliver drug at various times or at various sites in the body, according to a stimulus that is either endogenous or externally applied. In the past three decades, research along these lines has taken numerous directions, and each new generation of investigators has discovered new physicochemical principles and chemical schemes by which the release properties of materials can be altered. No single review could possibly do justice to all of these approaches. In this article, some general observations are made, and a partial history of the field is presented. Both open loop and closed loop systems are discussed. Special emphasis is placed on stimuli-responsive hydrogels, and on systems that can respond repeatedly. It is argued that the most success at present and in the foreseeable future is with systems in which biosensing and actuation (i.e. drug delivery) are separated, with a human and/or cybernetic operator linking the two.
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影响因子：
7.4
作者：
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通讯作者：
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